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Table 3 Genital infections and risk for PROM in Mulago Hospital

From: Genital infections and risk of premature rupture of membranes in Mulago Hospital, Uganda: a case control study

Variable Unadjusted odds ratio (95 % CI) Adjusted odds ratio (95 %) in model 1 Adjusted odds ratio (95 %) in model 2a Adjusted odds ratio (95 %) in model 3b
Abnormal vaginal discharge
 Yes 2.02 (1.10–3.70) 2.30 (1.18–4.47) 2.30 (1.18–4.40) 2.30 (1.18–4.46)
 No     
HIV status
 Positive 0.99 (0.42–2.34) 1.38 (0.51–3.75) 1.30 (0.51–3.72) 1.38 (0.51–3.75)
 Negative     
Trichomonas vaginalis
 Positive 2.98 (1.18–7.56) 4.22 (1.51–11.80) 3.70 (0.92–14.90)  
 Negative     
Chlamydia trachomatis
 Positive 2.05 (0.37–11.49) 1.91 (0.30–12.22) 1.92 (0.30–12.20)  
 Negative     
Candida
 Positive 0.27 (0.14–0.52) 0.22 (0.10–0.46) 0.16 (0.02–1.22) 0.22 (1.51–11.83)
 Negative     
HSV-2
 Positive 1.15 (0.63–2.09) 0.95 (0.48–1.88) 0.94 (0.48–1.87) 0.95 (0.48–1.88)
 Negative     
 Trichomonas and candida 0.49 (0.27–0.90)   1.34 (0.16–11.10) 1.34 (0.16–11.10)
 Trichomonas and Chlamydia 3.09 (1.21–7.84)    4.22 (1.51–11.83)
  1. In this table we have three models after multivariable analysis. Model 1 included abnormal vaginal discharge, HIV status Trichomonas vaginalis, Chlamydia trachomatis, candidiasis and HSV-2 serostatus. The italicized odds ratios were either independent risk factors for PROM (abnormal vaginal discharge and Trichomonas) or protective factors (candidiasis). Model 2 is included to assess whether co-infection with Trichomoniasis and candidiasis was a risk factor for premature rupture of membranes and found that this interaction was not a risk factor for PROM at multivariable analysis. Model 3 is included to assess whether co-infection with Trichomonas vaginalis and Chlamydia trachomatis was associated with PROM and it is shown that this interaction is a risk factor for PROM
  2. aThe model 2 assesses interactions between Trichomonas vaginalis and candidiasis
  3. bThe model 3 assesses interaction between Trichomonas vaginalis and Chlamydia trachomatis