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Table 1 Characteristics of subjects diagnosed with primary HIV-associated thrombocytopenia in the US Military Natural History Study 1986–2013

From: Impact of the highly active antiretroviral therapy era on the epidemiology of primary HIV-associated thrombocytopenia

  Pre-HAART era
1986–1995
Early HAART era
1996–2001
Later HAART era
2002–2013
P value
No. of cases 151 37 30  
Median age (yrs) (IQR) 32 (27, 38) 34 (31, 39) 36 (29, 41) NS
Male gender 138 (91.4 %) 36 (97.3 %) 30 (93.3 %) NS
Race     NS
 Caucasian 87 (57.6 %) 25 (67.6 %) 17 (56.7 %)  
 African–American 52 (34.4 %) 9 (24.3 %) 10 (33.3 %)  
 Hispanic 10 (6.6 %) 2 (5.4 %) 2 (6.7 %)  
 Other 2 (1.4 %) 1 (2.7 %) 1 (3.3 %)  
Nadir platelet count
 <50 × 109/l 73 (48.3 %) 11 (29.7 %) 6 (20.0 %) 0.005
 <20 × 109/l 33 (21.8 %) 6 (16.2 %) 4 (13.3 %) NS
CD4 count (cells/μl)
 ≤100 59 (39.1 %) 9 (24.3 %) 2 (6.7 %)  
 101–200 20 (13.2 %) 6 (16.2 %) 1 (3.3 %)  
 201–350 26 (17.2 %) 11 (29.7 %) 10 (33.3 %)  
 351–500 19 (12.6 %) 4 (10.8 %) 8 (26.7 %)  
 >500 26 (17.2 %) 6 (16.2 %) 9 (30.0 %)  
 Not determined 1 (0.7 %) 1 (2.7 %)   
 Median (IQR) 156 (30, 406) 262 (148, 378) 380 (255, 517) <0.001
  1. HAART highly active antiretroviral therapy, IQR interquartile range