TY - JOUR AU - Auger, Jean-Philippe AU - Christodoulides, Myron AU - Segura, Mariela AU - Xu, Jianguo AU - Gottschalk, Marcelo PY - 2015 DA - 2015/10/26 TI - Interactions of Streptococcus suis serotype 2 with human meningeal cells and astrocytes JO - BMC Research Notes SP - 607 VL - 8 IS - 1 AB - Streptococcus suis serotype 2 is an important porcine pathogen and emerging zoonotic agent responsible for meningitis, of which different sequence types predominate worldwide. Though bacterial meningitis is defined as an exacerbated inflammation of the meninges, the underlying astrocytes of the glia limitans superficialis may also be implicated. However, the interactions between this pathogen and human meningeal cells or astrocytes remain unknown. Furthermore, the roles of well-described virulence factors (capsular polysaccharide, suilysin and cell wall modifications) in these interactions have yet to be studied. Consequently, the interactions between S. suis serotype 2 and human meningeal cells or astrocytes were evaluated for the first time in order to better understand their involvement during meningitis in humans. SN - 1756-0500 UR - https://doi.org/10.1186/s13104-015-1581-2 DO - 10.1186/s13104-015-1581-2 ID - Auger2015 ER -