Evaluation of leishmanicidal activity and cytotoxicity of Ricinus communis and Azadirachta indica extracts from western Kenya: in vitro and in vivo assays

Table 4 Optimal efficacy, IC₉₀ and IC₅₀ of test extracts against amastigote form of the parasite

Concentration (µg/mL)	Test drugs					Parameter and statistics
	Az	Rc	Az + Rc	Pento	AMB	F value	p value
Optimal efficacy (%)	72	59.5	88	98	92	17.311	0.002
Concentration at optimal efficacy	25.5	28.2	35.1	25.2	34.5	9.212	0.001
IC₉₀	–	–	34.5	15.5	24.5	19.221	0.001
IC₅₀	11.5	16.5	9.0	6.5	4.5	12.489	0.000

Az, A. indica; Rc: R. communis; Az + Rc combination of A. indica and R. communis; Pento, pentostam; AMB, amphotericin B

ISSN: 1756-0500