Lipid levels in HIV-positive men receiving anti-retroviral therapy are not associated with copy number variation of reverse cholesterol transport pathway genes

Marino, Rebecca B.; Kingsley, Lawrence A.; Hussain, Shehnaz K.; Bream, Jay H.; Penogonda, Sudhir; Duggal, Priya; Martinson, Jeremy J.

doi:10.1186/s13104-015-1665-z

Table 3 Reverse Cholesterol Transport (RCT) pathway genes selected for analysis

From: Lipid levels in HIV-positive men receiving anti-retroviral therapy are not associated with copy number variation of reverse cholesterol transport pathway genes

Gene name	Symbol	Chromo-some	Function	References
Scavenger receptor class B, member 1	SRBI	12	Plasma membrane receptor for HDL that mediates transfer of cholesterol to and from HDL	[33]
Apolipoprotein C-III	APOC3	11	Very low density lipoprotein that inhibits lipoprotein lipase and hepatic lipase delaying triglyceride-rich particle catabolism	[32]
Apolipoprotein A-I	APOA1	11	Major protein component of HDL and a cofactor of LCAT. Defects in APOA1 results in HDL deficiencies	[32, 33]
Apolipoprotein E	APOE	19	Main apoprotein of chylomicron and essential for catabolism of triglyceride-rich lipoprotein constituents	[32, 33]
Phospholipid Transfer Protein	PLTP	20	Lipid transfer protein that transfers phospholipids from triglyceride-rich lipoproteins to HDL	[33]
Hepatic Lipase	LIPC	15	Triglyceride hydrolase and ligand/bridging factor for receptor mediated lipoprotein uptake	[32, 33]
Lecithin-cholesterol Acyltransferase	LCAT	16	Extracellular cholesterol esterifying enzyme that esterifies cholesterol for transport	[32, 33]
Apolipoprotein A-IV	APOA4	11	Potent activator of lecithin-cholesterol acyltransferase	[32]
Lipoprotein Lipase	LPL	8	Triglyceride hydrolase and ligand/bridging factor for receptor mediated lipoprotein uptake	[32, 33]
Endothelial Lipase	LIPG	18	Regulates circulating levels of HDL and acts has phospholipase activity	[33]
Low Density Lipoprotein Receptor	LDLR	19	Cell surface protein involved in receptor-mediated endocytosis of LDL	[32, 33]
Cholesteryl ester transfer protein	CETP	16	Transfers cholesteryl esters between lipoproteins	[32, 33]
Apolipoprotein A-V	APOA5	11	Component of high density lipoprotein	[32]
Apolipoprotein B	APOB	2	Main apolipoprotein of chylomicrons and low density lipoproteins	[32]
ATP-binding cassette, sub-family A, member 1	ABCA1	9	Membrane associated protein that functions as a cholesterol efflux pump in the cellular lipid removal pathway	[32, 33]
Apolipoprotein C-II	APOC2	19	Plasma lipid-binding protein that activates lipoprotein lipase	[32]

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ISSN: 1756-0500

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