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Table 3 Reverse Cholesterol Transport (RCT) pathway genes selected for analysis

From: Lipid levels in HIV-positive men receiving anti-retroviral therapy are not associated with copy number variation of reverse cholesterol transport pathway genes

Gene name Symbol Chromo-some Function References
Scavenger receptor class B, member 1 SRBI 12 Plasma membrane receptor for HDL that mediates transfer of cholesterol to and from HDL [33]
Apolipoprotein C-III APOC3 11 Very low density lipoprotein that inhibits lipoprotein lipase and hepatic lipase delaying triglyceride-rich particle catabolism [32]
Apolipoprotein A-I APOA1 11 Major protein component of HDL and a cofactor of LCAT. Defects in APOA1 results in HDL deficiencies [32, 33]
Apolipoprotein E APOE 19 Main apoprotein of chylomicron and essential for catabolism of triglyceride-rich lipoprotein constituents [32, 33]
Phospholipid Transfer Protein PLTP 20 Lipid transfer protein that transfers phospholipids from triglyceride-rich lipoproteins to HDL [33]
Hepatic Lipase LIPC 15 Triglyceride hydrolase and ligand/bridging factor for receptor mediated lipoprotein uptake [32, 33]
Lecithin-cholesterol Acyltransferase LCAT 16 Extracellular cholesterol esterifying enzyme that esterifies cholesterol for transport [32, 33]
Apolipoprotein A-IV APOA4 11 Potent activator of lecithin-cholesterol acyltransferase [32]
Lipoprotein Lipase LPL 8 Triglyceride hydrolase and ligand/bridging factor for receptor mediated lipoprotein uptake [32, 33]
Endothelial Lipase LIPG 18 Regulates circulating levels of HDL and acts has phospholipase activity [33]
Low Density Lipoprotein Receptor LDLR 19 Cell surface protein involved in receptor-mediated endocytosis of LDL [32, 33]
Cholesteryl ester transfer protein CETP 16 Transfers cholesteryl esters between lipoproteins [32, 33]
Apolipoprotein A-V APOA5 11 Component of high density lipoprotein [32]
Apolipoprotein B APOB 2 Main apolipoprotein of chylomicrons and low density lipoproteins [32]
ATP-binding cassette, sub-family A, member 1 ABCA1 9 Membrane associated protein that functions as a cholesterol efflux pump in the cellular lipid removal pathway [32, 33]
Apolipoprotein C-II APOC2 19 Plasma lipid-binding protein that activates lipoprotein lipase [32]