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Table 5 Differences in BSI caused by Gram positive and Gram negative bacteria, and between MDRs and non-MDRs

From: Bloodstream infections in patients with malignancies: implications for antibiotic treatment in a Ghanaian tertiary setting

Variables

Number

Antibiotic resistance

MDRs (n = 40)

Non-MDRs (n = 49)

Odds ratio (95 % CI)

p value

Univariate analysis

     

 Male gender

     

  Yes

55

23

32

0.72 (0.31–1.69)

0.450

  No

34

17

17

  

 Age (± SD)

 

24.05 ± 2.41

31.09 ± 3.32

0.21 (0.19–0.79)

<0.001

 Paediatric patients

     

  Yes

58

20

38

0.29 (0.11–0.72)

0.007

  No

31

20

11

  

 Cancer type

     

  Leukemia

32

14

18

0.93 (0.9–2.21)

0.862

  Lymphoma

15

7

8

1.08 (0.35–3.30)

0.887

  Myeloma

4

1

3

0.39 (0.04–3.93)

0.624

  Solid cancer

10

4

6

0.79 (0.21–3.04)

1

  Undiagnosed

26

12

14

1.07 (0.43–2.68)

0.887

 Haematologic cancers

     

  Yes

 

31

23

3.89 (1.53–9.86)

0.003

  No

 

9

26

  

 Febrile neutropenia

21

10

11

1.15 (0.43–3.07)

0.778

 Others

68

30

38

  

 Year of infection

     

  2010

18

8

10

0.97 (0.34–2.76)

1

  2011

29

16

15

1.51 (0.63–3.63)

0.353

  2012

31

17

14

1.84 (0.76–4.46)

0.17

  2013

11

5

6

1.02 (0.29–3.63)

1

 Patient location

     

  Child health

46

20

26

0.86 (0.38–2.04)

0.778

  Haematology

25

12

13

1.18 (0.47–2.99)

0.718

  Others

15

7

8

1.08 (0.36–3.31)

0.887

 CTX resistance

    

0.001

  Yes

40

26

14

4.64 (1.89–11.39)

 

  No

49

14

35

  

 Gram negatives

     

  Yes

49

34

15

12.8 (4.45–37.05)

<0.001

  No

40

6

34

  

 Enterobactericeae

     

  Yes

32

28

4

26.2 (7.70–89.44)

<0.001

  No

57

12

45

  

 Pseudomonads

     

  Yes

10

0

10

0.004

  No

79

40

39

  

 Multivariate factor(s)

     
 

Enterobacteriaceae

33.6 (6.41–88.73)

<0.001

  
  1. Odds ratio in multivariate analysis were adjusted for age, paediatric patients, cefotaxime resistance, Gram-negative bacteria, Enterobacteriaceae and Pseudomonads
  2. MDRs multidrug resistant strains, CI confidence interval, SD standard deviation, CTX cefotaxime