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Table 1 Summary and pooled analysis of non-randomized studies of patients presenting with acute ischemic mitral regurgitation

From: Surgical versus medical management of patients with acute ischemic mitral regurgitation: a systematic review

Study Study type Year N Age (years) NYHA III–IV (%) EF % <30 day mortality (N) 1–12 months mortalitya (N) 1–15 year mortalitya (N)
MVR No MVR MVR No MVR MVR No MVR
Nishimura [16] Case series 1986 7 57 100 49 0/7 (–) 3/7 (–) 1/7 (–)
Kishon [17]b Retrospective 1992 22 68    6/22 (–) (–) (–) 6/22 (–)
Tcheng [9] Retrospective 1992 50 68   35 (–) 16/50 (–) 25/50 (–) (–)
Gillinov [18] Retrospective 2001 95     7/95 (–) 6/95 (–) 74/95 (–)
Minami [19]b Retrospective 2004 6   100 57 2/6 (–) (–) (–) (–) (–)
Russo [20]b Prospective 2008 54 70 98 56 2/54 (–) (–) (–) (–) (–)
Lorusso [21]b Retrospective 2008 126 62 66 # 34/126 (–) (–) (–) 8/126 (–)
Thompson [6] Prospective 2009 94 71 100 37 17/43 36/51 (–) (–) (–) (–)
Pooled    454 67 91 42 68/353 52/101 9/102 25/50 89/252 (–)
  1. EF ejection fraction, MVR mitral valve repair or replacement, N number of patients with acute ischemic mitral regurgitation, NYHA New York Heart Association
  2. #Half of patients had left ventricular systolic dysfunction; (–), not applicable or no patients enrolled in that arm
  3. aThese is not cumulative mortality. To get cumulative mortality, add up the numbers where applicable
  4. bMixed studies including patients with papillary muscle rupture