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Table 1 Gene ontology (GO) enrichment analysis of 1611 SNPs identified at 10× coverage using SureSelect kit with P < 0.01

From: Preliminary evaluation of exome sequencing to identify genetic markers of susceptibility to tuberculosis disease

GO description Occurrences P values Link to tuberculosis
All genes Sample
Cellular response to ATP 7 4 3.23E−4 [41, 42]
Riboflavin metabolic process 5 3 1.71E−3  
Regulation of centriole replication 5 3 1.71E−3  
Axon guidance 281 28 2.98E−3  
Vitamin E metabolic process 2 2 3.27E−3 [43]
Epithelial cell proliferation 2 2 3.27E−3  
Response to cortisol stimulus 2 2 3.27E−3  
Negative regulation of retinal ganglion cell axon guidance 2 2 3.27E−3  
Cellular response to hormone stimulus 12 4 3.63E−3  
O-glycan processing 55 9 3.71E−3  
Regulation of small GTPase mediated signal transduction 121 15 3.75E−3  
Integrin-mediated signaling pathway 37 7 4.45E−3  
Purinergic nucleotide receptor signaling pathway 7 3 5.49E−3 [44]
Synaptic vesicle endocytosis 7 3 5.49E−3  
Negative regulation of phosphatase activity 49 8 6.18E−3  
Response to unfolded protein 30 6 6.26E−3 [45]
Autophagic vacuole fusion 8 3 8.41E−3 [46]
Nucleocytoplasmic transport 15 4 8.73E−3  
Small GTPase mediated signal transduction 158 17 8.93E−3  
Pre-B cell allelic exclusion 3 2 9.43E−3  
Pressure natriuresis 3 2 9.43E−3  
Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration 3 2 9.43E−3  
Positive regulation of telomere maintenance via telomerase 3 2 9.43E−3  
Lacrimal gland development 3 2 9.43E−3  
Roundabout signaling pathway 3 2 9.43E−3  
Leukotriene B4 catabolic process 3 2 9.43E−3  
Vitamin K biosynthetic process 3 2 9.43E−3  
Metaphase plate congression 3 2 9.43E−3  
Regulation of endopeptidase activity 3 2 9.43E−3  
Apoptotic process involved in luteolysis 3 2 9.43E−3