Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication

BMC Research Notes

Table 1 Summary of the investigations during the first 18 days of hospital stay

Investigation	D1	D2	D3	D4	D5	D6	D7	D8	D9	D10	D11	D12	D13	D14	D15	D16	D17	D18
WBC (×10³/μl)	0.20	0.32	0.40	0.60	0.60	0.80	0.32	0.61	0.82	1.0	3.5	9.5	20	27.7	35.5	37.2	36.1	29.4
ANC (×10³/μl)	0.11	0.10	0.16	0.09	0.12	0.14	0.14	0.28	0.15	0.34	1.8	6.9	16.5	21.6	28	29.6	31	25
Hb (g/dl)	12.2	11.1	10.7	11.5	9.6	9.5	8.9	8.4	8.7	8.1	8.8	8.7	8.3	8.4	8.5	8.2	7.1	8.4
RBC (×10⁶/μl)	4.19	4.21	3.95	3.95	4.01	4.65	3.56	3.88	4.28	4.94	4.22	3.98	4.11	4.55	4.82	4.77	4.36	4.29
MCV (fL)	84	85	85.4	85.3	85.4	84	83.1	86	84.1	83.1	85	84.2	83.2	85	84.1	86	86.2	85.3
MCH (pg)	32.0	30.1	29.8	30	28.8	29.1	31	32.2	31.3	33	34	32.1	33.4	32	34	33.1	33	33.2
MCHC (g/dl)	34.9	35.1	34.9	35.2	33.7	34.4	35	35.2	33	34	33.2	34	33.2	35	35.2	34.8	33.8	32.7
PCV (%)	35	33	30	36	28	27	27	25	25	26	24	26	26	25	26	25	22	26
Plt (×10³/μl)	97	79	53	82	75	64	70	57	89	144	196	247	254	232	212	200	201	283
ALT (IU/l)		43	42			35	63	58	60	53	48	56	62	49	38	23		30
AST (IU/l)		103	114			67	108	70	65	68	74	80	68	52	50	65		42
Alb (g/l)						22			23			28				26
Prot (g/l)						44			56			60				60
S cr (μmol/l)		56.2				71	75	64	51	47			66			73		68
BU (mmol/l)	15.7	14.9			9.3	7.0	6.7	4.3	4.3	4.6	3.8	4.2	5.0	4.8	3.8	2.5
Na⁺ (mmol/l)	134	132			140	147	148	154	132	153	143	140	138	132	136	145	138	136
K⁺ (mmol/l)	4.4	3.6			3.5	3.8	3.3	3.4	4.1	5.3	4.8	3.9	4.0	3.1	3.0	3.2	4.1	4.8
CRP (mg/l)				270						30								34

WBC white blood cells, ANC absolute neutrophil count, Hb hemoglobin, RBC red blood cell count, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PCV pack cell volume, Plt platelet, ALT alanine transaminase, AST aspartate transaminase, Alb albumin, Prot total protein, S cr serum creatinine, BU blood urea, Na ⁺ serum sodium, K ⁺ serum potassium, CRP C reactive protein

ISSN: 1756-0500