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Fig. 5 | BMC Research Notes

Fig. 5

From: Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum

Fig. 5

Intestinal permeability studied in ileum of controls (C, left panel) and buserelin (B, right panel)-treated rats. Buserelin treatment did not affect baseline permeability in the ileum. Carbachol treatment of ileum in controls significantly enhanced the permeability of d-(1-14C)-mannitol (2.9 kBq/mL), fluorescein isothiocyanate (FITC)-dextran (FD4) (1 mg/mL), and at 120 min also bovine serum albumin (BSA) (25 mg/mL), compared with the untreated ileum. Carbachol treatment (10 mM) failed to enhance the permeability of ileum from buserelin-treated rats. C = 7 rats and B = 11 rats. Results are presented as medians and interquartile ranges and were analyzed by the Mann–Whitney U-test. Statistical significance is indicated by *p < 0.05 and **p < 0.01

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