Fig. 1
From: A cancer cell-line titration series for evaluating somatic classification
The eight cell-line titration libraries were mapped with Novoalign and BWA, collapsed with Picard and optionally realigned and recalibrated with GATK. All somatic variant calling tools were applied to the collapsed Novoalign reads without GATK processing for the Phase 1 evaluation. MuTect and Strelka were applied to Novoalign and BWA reads with and without GATK processing to create the eight pipelines evaluated in Phase 2