TY - JOUR AU - Bourdeau, Annie AU - Van Slyke, Paul AU - Kim, Harold AU - Cruz, Maribelle AU - Smith, Tracy AU - Dumont, Daniel J. PY - 2016 DA - 2016/05/28 TI - Vasculotide, an Angiopoietin-1 mimetic, ameliorates several features of experimental atopic dermatitis-like disease JO - BMC Research Notes SP - 289 VL - 9 IS - 1 AB - Earlier studies by our group have demonstrated that a transgenic animal engineered to express Tie2 under the control of the Tie2 promoter produced animals with a scaly skin phenotype that recapitulated many of the hallmarks of atopic dermatitis (AT-Derm). To test the hypothesis that this model of AT-Derm is driven by dysregulated Tie2-signalling, we have bred AT-Derm transgenic (TG) animals with TG-animals engineered to overexpress Angiopoietin-1 or -2, the cognate Tie2 ligands. These two ligands act to antagonize one another in a context-dependent manner. To further evaluate the role of Ang1-driven-Tie2 signalling, we examined the ability of Vasculotide, an Ang1-mimetic, to modulate the AT-Derm phenotype. SN - 1756-0500 UR - https://doi.org/10.1186/s13104-015-1817-1 DO - 10.1186/s13104-015-1817-1 ID - Bourdeau2016 ER -