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Table 1 HBPs differentially regulated in periodontal disease

From: In silico analyses of heparin binding proteins expression in human periodontal tissues

Protein name Protien abbreviation
Up regulated HBPs  
 ADAM metallopeptidase with thrombospondin type 1 motif, 1 ADAMTS1
 Arginase, liver ARG1
 Chemokine (C–C motif) ligand 19 CCL19
 Complement factor H CFH
 Chemokine (C–X–C motif) ligand 1 CXCL1
 Chemokine (C–X–C motif) ligand 12 CXCL12
 Chemokine (C–X–C motif) ligand 13 (B cell chemoattractant) CXCL13
 Chemokine (C–X–C motif) ligand 2 CXCL2
 Chemokine (C–X–C motif) ligand 6 (granulocyte chemotactic protein 2) CXCL6
 Fibronectin 1 FN1
 Heparin-binding EGF-like growth factor HBEGF
 Insulin-like growth factor 2 mRNA binding protein 3 IGFBP6
 Interleukin 10 IL10
 Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) IL12B
 Interleukin 6 (interferon, beta 2) IL6
 Interleukin 8 IL8
 Inhibin, beta A (activin A, activin AB alpha polypeptide) INHBA
 Lactotransferrin LTF
 Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase) MMP2
 Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase) MMP9
 Plasminogen activator, urokinase PLAU
 Serpine peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 SERPINE1
 Tenascin C (hexabrachion) TNC
 Tumour necrosis factor TNF
 Vascular endothelial growth factor VEGFA
Down regulated HBPs
 Amyloid P component, serum APCS
 Chemokine (C–C motif) ligand 2 CCL2
 Chemokine (C–C motif) ligand 3 CCL3
 Chemokine (C–C motif) ligand 4 CCL4
 Chemokine (C–C motif) ligand 5 CCL5
 CD36 molecule CD36
 Complement factor B CFB
 Connective tissue growth factor CTGF
 Chemokine (C–X–C motif) ligand 10 CXCL10
 Fibroblast growth factor 2 (basic) FGF2
 Fibroblast growth factor receptor 3 FGFR3
 Fibronectin FN1
 Glycoprotein (transmembrane) GPNMB
 Interferon, gamma IFNG
 Insulin-like growth factor binding protein 2, 36 kDa IGFBP2
 Interleukin 2 IL2
 Interleukin 6 (interferon, beta 2) IL6
 Interleukin 8 IL8
 Matrix metallopeptidase 14 (membrane-inserted) MMP14
 Urokinase PLAU
 Thyroglobulin TG
 Thrombospondin 1 THBS1
 Tumour necrosis factor TNF
  1. Analyses using published data sets show 25 up-regulated and 23 down-regulated HBPs in periodontitis