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Table 2 Primary and secondary endpoint measures: baseline vs week-6 (n = 15)

From: Effect of late sodium current inhibition on MRI measured diastolic dysfunction in aortic stenosis: a pilot study

Parameter

Baseline

Week-6

p (paired t test)

MRI parameters

 PEDSR (1/s)

0.79 ± 0.151

0.86 ± 0.181

0.198

 PSS (%)

−17.44 ± 2.57

−17.53 ± 3.98

0.907

 PSSR (1/s)

−0.99 ± 0.203

−1.04 ± 0.208

0.436

 MPR

2.68 ± 0.634

2.52 ± 0.614

0.452

 LVEDV (ml)

173.7 ± 47.64

170.1 ± 59.02

0.624

 LVESV (ml)

73.3 ± 25.26

74.3 ± 29.38

0.509

 EF (%)

58.3 ± 3.81

56.7 ± 4.81

0.080

Exercise parameters

 Resting HR (bpm)

74.5 ± 11.8

74.4 ± 13.7

0.963

 Resting SBP (mmHg)

153.0 ± 23.6

147.2 ± 17.3

0.208

 Exercise duration (min)

10.47 ± 3.68

11.60 ± 3.25

0.062

 Max HR (bpm)

143.5 ± 10.7

139.6 ± 15.5

0.273

 Max SBP (mmHg)

182.9 ± 20.5

174.5 ± 25.8

0.133

 Resting LVRPP (mmHg.bpm)

14,424.3 ± 3054.0

14,514.1 ± 3591.6

0.903

 Exercise LVRPP (mmHg.bpm)

36,041.3 ± 5235.1

34,516.9 ± 6538.4

0.313

Biomarker

 NT-proBNP (pmol/L)

48.54 ± 82.43

51.64 ± 73.28

0.715

Echocardiographic parameters

 E/A

0.773 ± 0.163

0.783 ± 0.169

0.765

 Septal E/e’

12.94 ± 3.91

13.79 ± 2.86

0.258

 Lateral E/e’

10.65 ± 3.49

10.62 ± 3.43

0.979

  1. Abbreviations as Table 1. PEDSR peak early diastolic strain rate, PSS peak systolic strain, PSSR peak systolic strain rate, MBF myocardial blood flow, MPR myocardial perfusion reserve, LVESV left ventricular end systolic volume, HR heart rate, SBP systolic blood pressure. All p > 0.05