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Table 2 Primary and secondary endpoint measures: baseline vs week-6 (n = 15)

From: Effect of late sodium current inhibition on MRI measured diastolic dysfunction in aortic stenosis: a pilot study

Parameter Baseline Week-6 p (paired t test)
MRI parameters
 PEDSR (1/s) 0.79 ± 0.151 0.86 ± 0.181 0.198
 PSS (%) −17.44 ± 2.57 −17.53 ± 3.98 0.907
 PSSR (1/s) −0.99 ± 0.203 −1.04 ± 0.208 0.436
 MPR 2.68 ± 0.634 2.52 ± 0.614 0.452
 LVEDV (ml) 173.7 ± 47.64 170.1 ± 59.02 0.624
 LVESV (ml) 73.3 ± 25.26 74.3 ± 29.38 0.509
 EF (%) 58.3 ± 3.81 56.7 ± 4.81 0.080
Exercise parameters
 Resting HR (bpm) 74.5 ± 11.8 74.4 ± 13.7 0.963
 Resting SBP (mmHg) 153.0 ± 23.6 147.2 ± 17.3 0.208
 Exercise duration (min) 10.47 ± 3.68 11.60 ± 3.25 0.062
 Max HR (bpm) 143.5 ± 10.7 139.6 ± 15.5 0.273
 Max SBP (mmHg) 182.9 ± 20.5 174.5 ± 25.8 0.133
 Resting LVRPP (mmHg.bpm) 14,424.3 ± 3054.0 14,514.1 ± 3591.6 0.903
 Exercise LVRPP (mmHg.bpm) 36,041.3 ± 5235.1 34,516.9 ± 6538.4 0.313
Biomarker
 NT-proBNP (pmol/L) 48.54 ± 82.43 51.64 ± 73.28 0.715
Echocardiographic parameters
 E/A 0.773 ± 0.163 0.783 ± 0.169 0.765
 Septal E/e’ 12.94 ± 3.91 13.79 ± 2.86 0.258
 Lateral E/e’ 10.65 ± 3.49 10.62 ± 3.43 0.979
  1. Abbreviations as Table 1. PEDSR peak early diastolic strain rate, PSS peak systolic strain, PSSR peak systolic strain rate, MBF myocardial blood flow, MPR myocardial perfusion reserve, LVESV left ventricular end systolic volume, HR heart rate, SBP systolic blood pressure. All p > 0.05