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Table 2 Treatment characteristics of children on first-line and second-line ART at National Pediatric Hospital

From: Factors associated with the failure of first and second-line antiretroviral therapies therapy, a case control study in Cambodian HIV-1 infected children

  First-line Second-line p
n = 175 % n = 57 %
Clinical status at ART onset
 WHO Stage I 37 21.1 5 8.8 0.06
 WHO Stage II 93 53.1 36 63.2  
 WHO Stage III 44 25.1 14 24.6  
 WHO Stage IV 1 0.6 2 3.5  
 Initial CD4 cells (%) 9.1 (3.9–12.9)   7.9 (2.5–12.8)   0.1
 Initial CD4 <15 % 147 84.0 52 91.2 0.17
 Time before ART onset (months) 2.6 (1.1–15.7)   2.5 (1.2–8.3)   0.1
At the time of survey
 Time on ART (months) 70.5 (43.9–90.8)   81.0 (71.4–92.5)   0.001
 Time since switch on second-line (months) NA   36.5 (19.6–55.9)   
 Time between VL and survey (months) 0.1 (0.1–4)   0.1(0.1–4)   0.7
 Non-adherence to ART 6 3.4 0   0.1
 Weight gain over 1 year (kg) 3.8 (3.5–4.2)   3.5 (2.7–4.2)   0.3
 Last CD4 cells (%) 27.8 (23.6–31.8)   22 (19.1–27)   <0.001
 CD4 cells <15 % 2 1.1 6 10.5  
Initial first-line treatment
 3TC + D4T + NVP 93 53.1 53 93.0  
 3TC + AZT + NVP 36 20.6    
 3TC + D4T + EFV 30 17.1 4 7.0  
 3TC + AZT + EFV 14 8.0    
 3TC + AZT + LPV 1 0.6    
 3TC + D4T + LPV 1 0.6    
Current second-line treatment
 ABC + DDI + LPV    31 54.4  
 3TC + TDF + LPV    13 22.8  
 3TC + DDI + LPV    3 5.3  
 3Tc + AZT + LPV    3 5.3  
 ABC + TDF + LPV    3 5.3  
 3TC + ABC + LPV    2 3.5  
 3TC + AZT + LPV    2 3.5  
  1. Numbers and (percentages). Median and (interquartile range)
  2. CI Confidence interval