Development of safe, effective and immunogenic vaccine candidate for diarrheagenic Escherichia coli main pathotypes in a mouse model

Table 1 E. coli pathotypes and mouse immunization and challenge groups used in the study

Immunization antigen (s) (whole-cell formalin-treated)	Challenge E. coli antigen (s) (live whole-cell)
Unadjuvanted, alum or CTB-adujvanted
Enteroaggregative E. coli (EAEC) (RKI 17-2)	EAEC
Enteroinvasive E. coli (EIEC) ATCC 43893 (O124: NM)	EIEC
Enterohaemorrhagic E. coli (EHEC) ATCC 43890 (O157:H7)	EHEC
Enteropathogenic E. coli (EPEC) [50, 51]	EPEC
Enterotoxigenic E. coli (ETEC) [50, 51]	ETEC
Combined antigens cocktail: EAEC, EPEC, EIEC, EHEC, ETEC	Combined cocktail
Controls
Formalin	Combined cocktail
PBS	Combined cocktail
	EAEC
	EPEC
	EIEC
	EHEC
	ETEC

ISSN: 1756-0500