Table 1 Distribution of the polymorphisms in IL-1A, IL4, NFKB1 and PAR1 genes in Brazilian regions and parental populations

IL1A

(rs3783553)

180

187

186

184

191

222

211

268

Ins/Ins

52 (28.9)

89 (47.6)

57 (30.6)

91 (49.5)

102 (53.4)

08 (13.5)

129 (61.1)

132 (33.7)

Ins/Del

92 (51.1)

77 (41.2)

100 (53.8)

74 (40.2)

70 (36.6)

65 (45.5)

71 (33.7)

111 (55.9)

Del/Del

36 (20.0)

21 (11.2)

29 (15.6)

19 (10.3)

19 (10.0)

149 (41.0)

11 (5.2)

25 (10.4)

Ins

0.545

0.682

0.575

0.696

0.717

0.182

0.780

0.700

Del

0.455

0.318

0.425

0.304

0.283

0.818

0.220

0.300

IL4

(rs79071878)

180

187

186

184

191

222

211

268

A3/A3

61 (33.9)

109 (58.3)

104 (55.9)

98 (53.3)

114 (60.0)

12 (5.4)

22 (10.4)

143 (53.3)

A3/A2

89 (49.4)

72 (38.5)

70 (37.6)

78 (42.4)

69 (36.3)

77 (34.7)

133 (63.0)

109 (40.7)

A2/A2

30 (16.7)

06 (3.2)

12 (6.5)

08 (4.3)

07 (3.7)

133 (59.9)

56 (26.6)

16 (6.0)

A3

0.586

0.775

0.747

0.745

0.782

0.227

0.420

0.737

A2

0.414

0.225

0.253

0.255

0.218

0.773

0.580

0.263

NFKB1

(rs28362491)

180

187

185

184

191

222

211

268

Ins/Ins

34 (18.9)

75 (40.0)

62 (33.5)

61 (33.2)

73 (38.2)

30 (13.5)

47 (22.3)

90 (33.6)

Ins/Del

99 (55.0)

80 (43.0)

88 (47.6)

88 (47.8)

93 (48.7)

101 (45.5)

109 (51.7)

151 (56.3)

Del/Del

47 (26.1)

32 (17.0)

35 (18.9)

35 (19.0)

25 (13.1)

91 (41.0)

55 (26.0)

27 (10.1)

Ins

0.464

0.615

0.573

0.571

0.626

0.363

0.481

0.617

Del

0.536

0.385

0.427

0.429

0.374

0.637

0.519

0.383

PAR1

(rs11267092)

180

187

186

183

191

222

199

267

Ins/Ins

11 (6.1)

17 (9.1)

18 (9.8)

22 (12.0)

16 (8.4)

02 (0.9)

56 (28.1)

12 (4.5)

Ins/Del

56 (31.1)

76 (40.6)

67 (36.0)

64 (35.0)

61 (31.9)

17 (7.7)

86 (43.2)

98 (36.7)

Del/Del

113 (62.8)

94 (50.3)

101 (54.3)

97 (53.0)

114 (59.7)

203 (91.4)

57 (28.7)

157 (58.8)

Ins

0.217

0.294

0.277

0.295

0.243

0.047

0.497

0.228

Del

0.783

0.706

0.723

0.705

0.757

0.953

0.503

0.772