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Table 2 Drug interaction between cisplatin and BMS-754807

From: BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549

Cell line Cisplatin (μM) BMS-754807 (µM) Interactiona
A549 0.5 0.01 Synergistic
A549 1.0 0.01 Synergistic
A549 2.5 0.01 Synergistic
A549 0.5 0.1 Synergistic
A549 1.0 0.1 Synergistic
A549 2.5 0.1 Synergistic
A549 0.5 0.25 Synergistic
A549 1.0 0.25 Synergistic
A549 2.5 0.25 Synergistic
NCI-H358 2.5 0.001 Antagonistic
NCI-H358 5.0 0.001 Antagonistic
NCI-H358 7.5 0.001 Antagonistic
NCI-H358 2.5 0.1 Additive
NCI-H358 5.0 0.1 Additive
NCI-H358 7.5 0.1 Additive
NCI-H358 2.5 0.25 Antagonistic
NCI-H358 5.0 0.25 Additive
NCI-H358 7.5 0.25 Additive
  1. aCombination index <1 = synergistic interaction, combinations index ~1
  2.  = additive interaction, combination index >1 = antagonistic interaction