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Table 3 Drug interaction between carboplatin and BMS-754807

From: BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549

Cell line

Carboplatin (µM)

BMS-754807 (µM)

Interactiona

A549

10

0.01

Synergistic

A549

25

0.01

Antagonistic

A549

50

0.01

Synergistic

A549

10

0.1

Synergistic

A549

25

0.1

Additive

A549

50

0.1

Synergistic

A549

10

0.25

Synergistic

A549

25

0.25

Synergistic

A549

50

0.25

Synergistic

NCI-H358

50

0.001

Antagonistic

NCI-H358

75

0.001

Antagonistic

NCI-H358

100

0.001

Additive

NCI-H358

50

0.1

Antagonistic

NCI-H358

75

0.1

Antagonistic

NCI-H358

100

0.1

Additive

NCI-H358

50

0.25

Antagonistic

NCI-H358

75

0.25

Antagonistic

NCI-H358

100

0.25

Additive

  1. acombination index <1 = synergistic interaction, combinations index ~1
  2.  = additive interaction, combination index >1 = antagonistic interaction