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Table 3 Drug interaction between carboplatin and BMS-754807

From: BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549

Cell line Carboplatin (µM) BMS-754807 (µM) Interactiona
A549 10 0.01 Synergistic
A549 25 0.01 Antagonistic
A549 50 0.01 Synergistic
A549 10 0.1 Synergistic
A549 25 0.1 Additive
A549 50 0.1 Synergistic
A549 10 0.25 Synergistic
A549 25 0.25 Synergistic
A549 50 0.25 Synergistic
NCI-H358 50 0.001 Antagonistic
NCI-H358 75 0.001 Antagonistic
NCI-H358 100 0.001 Additive
NCI-H358 50 0.1 Antagonistic
NCI-H358 75 0.1 Antagonistic
NCI-H358 100 0.1 Additive
NCI-H358 50 0.25 Antagonistic
NCI-H358 75 0.25 Antagonistic
NCI-H358 100 0.25 Additive
  1. acombination index <1 = synergistic interaction, combinations index ~1
  2.  = additive interaction, combination index >1 = antagonistic interaction