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Fig. 1 | BMC Research Notes

Fig. 1

From: HiView: an integrative genome browser to leverage Hi-C results for the interpretation of GWAS variants

Fig. 1

HiView snapshot of GWAS variant rs1447295. The left and right light blue bars highlight the location of GWAS variant rs1447295 and gene MYC, respectively. Using Hi-C data from human IMR90 cells, we observe five paired-end reads spanning between rs1447295 and the transcription start site of gene MYC, while the expected contact frequency is 0.8281. Such long-range chromatin interaction is statistically significant, with p-value 0.0016. Therefore, we hypothesize that gene MYC is a potential target of this likely regulatory GWAS variant rs1447295

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