Fig. 1

HiView snapshot of GWAS variant rs1447295. The left and right light blue bars highlight the location of GWAS variant rs1447295 and gene MYC, respectively. Using Hi-C data from human IMR90 cells, we observe five paired-end reads spanning between rs1447295 and the transcription start site of gene MYC, while the expected contact frequency is 0.8281. Such long-range chromatin interaction is statistically significant, with p-value 0.0016. Therefore, we hypothesize that gene MYC is a potential target of this likely regulatory GWAS variant rs1447295