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Table 1 CVC infection-related glomerulonephritis in published reports and our patients

From: Central venous catheter infection-related glomerulonephritis under long-term parenteral nutrition: a report of two cases

 

Ohara et al.

Kusaba et al.

Patient 1

Patient 2

Age, sex

13, M

59, F

12, M

24, F

Underlying disease

Short bowel syndrome

Post-radiation enteritis

MMIHS

MMIHS

Duration of CVC (years)

13

2

8

18

Blood culture

S. epidermidis

S. epidermidis

S. epidermidis (MSSE)

S. epidermidis (MRSE)

24 h CCr/e-GFR (mL/min/1.73 m2)

84.6/−

−/5.3

77.4/70.8

−/63.1

C3/C4/CH50

30/8/ <10

30/10/ <12

69/7.4/26.4

57/24/10.5

PR3-ANCA

N/D

<5

33

19

Renal pathology (positive IF)

MPGN C3, IgM, C1

Crescentic GN C3, IgM, IgG

MPGN C3, IgM, C1q

MPGN C3, IgM

Treatment

CVC removal

CVC removal

CVC removal

CVC removal

 

Cefazolin for 10 days

Cefazolin (3 g/day) for 10 days

Cefazolin (3 g/day) for 7 days

  

PSL 60 mg/day + MZR 150 mg/day for 10 days

MPT 2 courses + PSL 40 mg/day for 1 month

Outcome

Full recovery

ESRD

Full recovery

Full recovery

  1. MMIHS megacystis microcolon intestinal hypoperistasis syndrome, CVC central venous catheter, CCr creatinine clearance, e-GFR estimated glomerular filtration rate, GN glomerulonephritis, MPGN membranoproliferative glomerulonephritis, MPT methyl prednisolone pulse therapy, PSL prednisolone, ESRD end stage renal disease