Table 2 Comparison of the clinical and histopathological characteristics between the time periods 1982–2000 and 2001–2010
1982–2000 | 2001–2010 | P value | |
|---|---|---|---|
Number of patients | 130 | 205 | |
Age at diagnosis | 47.8 ± 11.8 (range 20–73) years | 49.2 ± 13.1 (range 16–81) years | 0.321 |
Gender | 108F (83.1 %) | 156F (76.1 %) | 0.128 |
22 M (16.9 %) | 49 M (23.9 %) | ||
Hyperthyroidism | 24/130 (19.2 %) | 22/205 (10.2 %) | 0.033 |
Graves | 7/24 (32 %) | 14/22 (61.9 %) | 0.019 |
Toxic Adenoma | 4/24 (16.6 %) | 2/22 (9.1 %) | 0.370 |
Toxic MNG | 13/24 (54.2 %) | 6/22 (27.3 %) | 0.064 |
Hashimoto | 15/130 (11.5 %) | 32/205 (15.6 %) | 0.296 |
Family history | 3/130 (2.3 %) | 2/205 (1 %) | 0.327 |
Singlenodular | 37/130 (28.5 %) | 50/205 (24.4 %) | 0.408 |
Multinodular | 93/130 (71.5 %) | 155/205 (75.6 %) | |
Incidental | 110/130 (84.6 %) | 164/205 (80 %) | 0.286 |
Non-incidental | 20/130 (15.4 %) | 41/205 (20 %) | |
Unifocal | 95/130 (73.1 %) | 120/205 (58.5 %) | 0.007 |
Multifocal | 35/130 (26.9 %) | 85/205 (41.5 %) | |
< or = 5 mm | 46/95 (48.4 %) | 63/120 (52.5 %) | 0.552 |
>5 mm (of unifocal cases) | 49/95 (51.6 %) | 57/120 (47.5 %) | |
Metastases | 0/130 (0 %) | 0/205 (0 %) | >0.999 |
Capsule involvement | 23/130 (17.7 %) | 45/205 (22 %) | 0.345 |
T > 1 and/or N > 0 | 15/130 (11.5 %) | 21/205 (10.2 %) | 0.709 |
Histological types | 75/130 (57.7 %) CPC | 95/205 (46.3 %) | 0.043 |
25/130 (19.2 %) EFVC | 36/205 (17.6 %) | 0.699 | |
11/130 (8.5 %) N-EFVC | 47/205 (22.9 %) | <0.001 | |
17/130 (13.1 %) SVC | 24/205 (11.7 %) | 0.709 | |
2/130 (1.5 %) T-CVC | 3/205 (1.5 %) | 0.956 | |
Total or near total thyroidectomy | 104/130 (80 %) | 188/205 (91.7 %) | 0.001 |
131I | 96/130 (73.8 %) | 163/205 (79.5 %) | 0.228 |
Follow up | 13.9 ± 6.6 (range 5–33) years | 8.5 ± 2.7 (range 5–14) years | <0.001 |
Recurrence | 1/130 (0.8 %) | 1/205 (0.5 %) | 0.745 |
Persistence | 3/130 (2.3 %) | 10/205 (4.9 %) | 0.235 |
Disease free | 126/130 (96.9 %) | 194/205 (94.6 %) | 0.324 |