Table 9 Gene-disease associations from gene-year and gene-country analysis
Gene | Disease associations for gene | Genes that share more diseases with this gene | Country associations for gene | |||
|---|---|---|---|---|---|---|
Disease name | Score | Gene name | # of shared diseases | Country name | # of abstracts | |
ERBB2 | Breast neoplasms | 0.414 | EGFR | 15 | United States | 4271 |
Mammary neoplasms, experimental | 0.4 | PTGS2 | 13 | Italy | 808 | |
Neoplasm metastasis | 0.396 | SOD2 | 12 | Japan | 806 | |
Adenocarcinoma | 0.363 | TP53 | 11 | China | 799 | |
Ovarian neoplasms | 0.331 | STAT3 | 10 | United Kingdom | 674 | |
Prostatic neoplasms | 0.329 | CCND1 | 10 | Germany | 620 | |
Lung neoplasms | 0.329 | ESR1 | 10 | France | 486 | |
Stomach neoplasms | 0.321 | KRAS | 9 | Canada | 433 | |
Cholangiocarcinoma | 0.308 | TNF | 9 | South Korea | 347 | |
Glioma | 0.306 | TNFSF10 | 9 | Spain | 329 | |
ESR1 | Breast neoplasms | 0.423 | SOD2 | 14 | United States | 5429 |
Alzheimer disease | 0.358 | EGFR | 13 | United Kingdom | 1249 | |
Neoplasm metastasis | 0.345 | PTGS2 | 12 | Japan | 918 | |
Carcinoma | 0.344 | TNF | 11 | China | 764 | |
Coronary artery disease | 0.342 | CDH1 | 10 | Italy | 727 | |
Migraine disorders | 0.333 | ACE | 10 | France | 569 | |
Obesity | 0.327 | ERBB2 | 10 | Germany | 517 | |
Leiomyoma | 0.327 | PTEN | 9 | Canada | 515 | |
Myocardial infarction | 0.323 | STAT3 | 9 | South Korea | 338 | |
Infertility, male | 0.321 | TP53 | 9 | Sweden | 299 | |
PGR | Breast neoplasms | 0.38 | EGFR | 7 | United States | 1887 |
Endometriosis | 0.346 | ESR1 | 6 | Japan | 456 | |
Carcinoma | 0.32 | ESR2 | 6 | Italy | 404 | |
Meningioma | 0.307 | STAT3 | 5 | China | 385 | |
Adenocarcinoma | 0.304 | EFEMP1 | 5 | United Kingdom | 311 | |
Mammary neoplasms, animal | 0.3 | CDH1 | 5 | France | 294 | |
Mammary neoplasms, experimental | 0.3 | PHB | 5 | Germany | 245 | |
Mesothelioma | 0.3 | PDGFA | 5 | Canada | 188 | |
Recurrence | 0.3 | STAT5A | 5 | South Korea | 169 | |
Malignant neoplasm breast | 0.126 | ENO1 | 5 | Sweden | 131 | |
EGF | Hypomagnesemia 4, renal | 0.6 | SOD2 | 11 | United States | 2199 |
Wounds and injuries | 0.4 | IL6 | 9 | United Kingdom | 408 | |
Breast neoplasms | 0.325 | MMP9 | 9 | Japan | 394 | |
Prostatic neoplasms | 0.322 | PTGS2 | 9 | China | 378 | |
Carcinoma, hepatocellular | 0.317 | TNF | 9 | Italy | 298 | |
Neoplasm metastasis | 0.315 | PTEN | 8 | Germany | 239 | |
Glioblastoma | 0.311 | EGFR | 8 | South Korea | 211 | |
Adenocarcinoma | 0.307 | IGF1 | 8 | Canada | 205 | |
Kidney diseases | 0.301 | IL8 | 8 | France | 173 | |
Stomach ulcer | 0.3 | TGFB1 | 7 | Spain | 112 | |
BRCA1 | Breast-ovarian cancer, familial, Susceptibility To, 1 | 0.7 | CDH1 | 7 | United States | 1845 |
Malignant neoplasm breast | 0.54 | CCND1 | 7 | United Kingdom | 395 | |
Malignant neoplasm of ovary | 0.44 | SOD2 | 7 | Canada | 304 | |
Breast neoplasms | 0.419 | BRCA2 | 6 | France | 222 | |
Mammary neoplasms, experimental | 0.4 | HRAS | 6 | The Netherlands | 218 | |
Ovarian neoplasms | 0.381 | STAT3 | 6 | Italy | 197 | |
Neoplasms | 0.375 | EGFR | 6 | China | 182 | |
Carcinoma | 0.366 | ERBB2 | 6 | Spain | 143 | |
Hereditary breast and ovarian cancer Syndrome | 0.359 | ESR1 | 6 | Germany | 140 | |
Prostatic neoplasms | 0.318 | AKT1 | 5 | Japan | 124 | |
BRCA2 | Fanconi anemia, complementation Group D1 | 0.7 | BRCA1 | 6 | United States | 885 |
Malignant neoplasm breast | 0.54 | CTNNB1 | 6 | United kingdom | 256 | |
Ovarian neoplasms | 0.464 | ERBB2 | 6 | Canada | 203 | |
Prostatic neoplasms | 0.409 | PTEN | 5 | Italy | 119 | |
Medulloblastoma | 0.401 | SOD2 | 5 | The Netherlands | 115 | |
Breast neoplasms | 0.392 | TNF | 5 | Germany | 102 | |
Hereditary breast and ovarian cancer Syndrome | 0.334 | TNFSF10 | 5 | France | 100 | |
Fanconi ANEMIA | 0.326 | AKT1 | 4 | Spain | 93 | |
Pancreatic neoplasms | 0.309 | BRIP1 | 4 | Australia | 73 | |
Wilms tumor | 0.3 | CDH1 | 4 | Israel | 70 | |
CDKN2A | Melanoma-pancreatic cancer syndrome | 0.6 | TP53 | 15 | United States | 1809 |
Melanoma, cutaneous malignant, susceptibility To, 2 | 0.6 | SOD2 | 12 | China | 431 | |
Lung neoplasms | 0.442 | KRAS | 9 | Japan | 340 | |
Stomach neoplasms | 0.411 | PTGS2 | 9 | United Kingdom | 325 | |
Esophageal neoplasms | 0.41 | ABCB1 | 7 | Italy | 297 | |
Neoplasms | 0.391 | CSF3 | 7 | France | 224 | |
Adenocarcinoma | 0.358 | EGFR | 7 | Germany | 218 | |
Glioma | 0.341 | ESR1 | 6 | South Korea | 202 | |
Precursor cell lymphoblastic leukemia-Lymphoma | 0.338 | MET | 6 | Canada | 186 | |
Carcinoma, non-small-cell lung | 0.332 | ERBB2 | 6 | Spain | 136 | |
ALPPL2 | Abortion, spontaneous | 0.3 | CEACAM1 | 1 | United States | 104 |
Parkinson disease | 0.003 | HSD17B1 | 1 | Germany | 32 | |
Stroke | 0.003 | IFI35 | 1 | United Kingdom | 30 | |
Carcinoma in situ | 0.001 | IFI44 | 1 | Italy | 28 | |
Seminoma | 0.001 | IFI6 | 1 | France | 18 | |
Retinal diseases | <0.001 | IFNA10 | 1 | Japan | 16 | |
Embryonal neoplasm | <0.001 | IGFBP1 | 1 | Canada | 13 | |
Carcinoma, embryonal | <0.001 | IGFBP6 | 1 | Greece | 11 | |
– | – | IL11 | 1 | The Netherlands | 9 | |
– | – | IL12B | 1 | China | 9 | |
CD99 | Chondrosarcoma, mesenchymal | 0.3 | PDGFRA | 1 | United States | 342 |
Neuroectodermal tumors, primitive, Peripheral | 0.012 | BCL2 | 1 | Japan | 77 | |
Sarcoma, ewing | 0.01 | IL1A | 1 | Germany | 74 | |
Breast neoplasms | 0.005 | MKI67 | 1 | Italy | 63 | |
Carcinoma | 0.005 | – | – | China | 56 | |
Neuroectodermal tumors, primitive | 0.004 | – | – | United Kingdom | 52 | |
Osteosarcoma | 0.003 | – | – | Canada | 37 | |
Neoplasms | 0.003 | – | – | France | 26 | |
Lymphoma | 0.003 | – | – | Australia | 24 | |
Adenocarcinoma | 0.003 | – | – | The Netherlands | 22 | |
CHI3L1 | Schizophrenia | 0.319 | TNF | 3 | United States | 90 |
Glioblastoma | 0.311 | MET | 3 | Japan | 17 | |
Glioma | 0.31 | MGMT | 2 | United Kingdom | 17 | |
Neoplasm invasiveness | 0.303 | TGM2 | 2 | Italy | 15 | |
Osteoarthritis | 0.301 | ACO1 | 2 | France | 12 | |
Asthma-related traits, susceptibility To, 7 | 0.3 | MMP9 | 2 | Denmark | 10 | |
Hypertension | 0.103 | GDNF | 2 | Germany | 6 | |
Asthma | 0.017 | FTL | 2 | Australia | 6 | |
Arthritis, rheumatoid | 0.009 | ENO1 | 2 | Finland | 5 | |
Neoplasm malignant | 0.005 | EGF | 2 | India | 5 | |
SOD1 | Amyotrophic lateral sclerosis 1 | 0.66 | TNF | 19 | United States | 265 |
Amyotrophic lateral sclerosis | 0.551 | SOD2 | 17 | Italy | 42 | |
Hypertension | 0.402 | IL6 | 15 | Japan | 40 | |
Deficiency diseases | 0.4 | PTGS2 | 14 | India | 39 | |
Motor neuron disease | 0.341 | NOS2 | 13 | China | 31 | |
Down syndrome | 0.323 | CAT | 13 | United Kingdom | 28 | |
Atherosclerosis | 0.31 | AGT | 11 | Germany | 26 | |
Diabetes mellitus, type 2 | 0.31 | IL1B | 10 | The Netherlands | 25 | |
Ischemia | 0.309 | IFNG | 10 | Turkey | 20 | |
Parkinson disease | 0.309 | ALB | 10 | Canada | 18 | |
AMN | Imerslund-grasbeck syndrome | 0.601 | TNF | 3 | United States | 138 |
Acute kidney injury | 0.3 | KNG1 | 3 | United Kingdom | 32 | |
Neurogenic inflammation | 0.3 | TAC1 | 3 | Germany | 22 | |
Edema | 0.3 | IL6 | 2 | Japan | 18 | |
Extravasation of diagnostic and Therapeutic Materials | 0.3 | POMC | 2 | China | 16 | |
anemia, megaloblastic | 0.003 | CALCA | 2 | Canada | 12 | |
adrenoleukodystrophy | 0.003 | PTGS2 | 2 | France | 10 | |
Nervous system malformations | 0.003 | INS | 2 | Italy | 9 | |
Malabsorption syndromes | 0.001 | KLK1 | 1 | The Netherlands | 9 | |
Adrenomyeloneuropathy | <0.001 | LCN2 | 1 | Australia | 7 | |
CD40LG | Hyper-igm immunodeficiency syndrome, Type 1 | 0.629 | CCL2 | 4 | United States | 66 |
Coronary artery disease | 0.306 | IL1B | 3 | Germany | 15 | |
Pneumonia | 0.3 | IL6 | 3 | United Kingdom | 12 | |
Amyotrophic lateral sclerosis | 0.3 | TNF | 3 | Japan | 11 | |
Hypersensitivity | 0.3 | IL8 | 3 | Italy | 10 | |
Necrosis | 0.3 | IFNG | 3 | Argentina | 9 | |
Hypertension, pulmonary | 0.3 | IL5RA | 2 | China | 9 | |
Diabetes mellitus, type 1 | 0.101 | HMOX1 | 2 | Australia | 7 | |
Enterocolitis, necrotizing | 0.1 | IL13 | 2 | Denmark | 6 | |
Periodontal diseases | 0.1 | IL17A | 2 | The Netherlands | 6 | |
CD79A | Agammaglobulinemia | 0.3 | BTK | 1 | United States | 22 |
Leukemia, lymphocytic, chronic, B Cell | 0.003 | CD19 | 1 | France | 8 | |
Lymphoma, non-hodgkin | 0.003 | IGLL1 | 1 | China | 7 | |
Lymphoma, B-cell | 0.003 | LRRC8A | 1 | Japan | 6 | |
Leukemia, myeloid, acute | 0.003 | – | – | India | 4 | |
Leukemia | 0.003 | – | – | Spain | 4 | |
Multiple myeloma | 0.003 | – | – | Sweden | 3 | |
Lymphoma | <0.001 | – | – | Belgium | 3 | |
Takayasu arteritis | <0.001 | – | – | Finland | 3 | |
Lymphoma, large B-Cell, diffuse | <0.001 | – | – | United Kingdom | 3 | |
PRL | Prolactinoma | 0.415 | DRD2 | 9 | United States | 294 |
Hyperprolactinemia | 0.412 | POMC | 8 | United Kingdom | 59 | |
Adenoma | 0.33 | IL6 | 6 | Italy | 55 | |
Lupus erythematosus, systemic | 0.325 | CYP19A1 | 6 | Canada | 40 | |
Pituitary neoplasms | 0.311 | TNF | 6 | France | 31 | |
Autistic disorder | 0.304 | ESR2 | 5 | Australia | 29 | |
Growth hormone-secreting pituitary Adenoma | 0.302 | AGT | 5 | Japan | 28 | |
Endometriosis | 0.301 | CNR1 | 5 | China | 23 | |
Hypopituitarism | 0.301 | CRH | 5 | Spain | 20 | |
Amenorrhea | 0.301 | CYP17A1 | 5 | India | 19 | |
AFP | Carcinoma, hepatocellular | 0.398 | MMP9 | 5 | United States | 46 |
Liver diseases | 0.303 | HMOX1 | 4 | Japan | 12 | |
Liver cirrhosis, experimental | 0.3 | ENO1 | 3 | China | 11 | |
Breast neoplasms | 0.3 | MMP2 | 3 | Germany | 8 | |
Mammary neoplasms, experimental | 0.3 | ESR1 | 3 | Italy | 7 | |
Liver neoplasms | 0.019 | HRAS | 3 | France | 6 | |
Recurrent malignant neoplasm | 0.015 | NOS2 | 3 | Canada | 5 | |
Hepatitis B | 0.014 | IGF1 | 3 | Ireland | 4 | |
Neoplasm malignant | 0.012 | PTGS2 | 3 | Turkey | 3 | |
Down syndrome | 0.011 | TNFSF10 | 3 | Singapore | 3 | |
POMC | Obesity | 0.454 | TNF | 22 | United States | 27 |
Proopiomelanocortin deficiency | 0.4 | IL6 | 17 | Italy | 10 | |
Cushing syndrome | 0.331 | AGT | 15 | Japan | 9 | |
Pituitary acth hypersecretion | 0.315 | IL1B | 15 | France | 7 | |
Adrenal cortex diseases | 0.309 | PTGS2 | 15 | United kingdom | 6 | |
Acth syndrome, ectopic | 0.306 | SOD2 | 14 | Spain | 5 | |
Heart failure | 0.304 | ALB | 12 | The netherlands | 5 | |
Spasms, infantile | 0.303 | INS | 12 | Germany | 4 | |
Hypertension | 0.303 | BDNF | 11 | Austria | 4 | |
Osteoporosis | 0.303 | CRH | 11 | Poland | 4 | |