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Table 9 Gene-disease associations from gene-year and gene-country analysis

From: Integrating text mining, data mining, and network analysis for identifying genetic breast cancer trends

Gene Disease associations for gene Genes that share more diseases with this gene Country associations for gene
Disease name Score Gene name # of shared diseases Country name # of abstracts
ERBB2 Breast neoplasms 0.414 EGFR 15 United States 4271
Mammary neoplasms, experimental 0.4 PTGS2 13 Italy 808
Neoplasm metastasis 0.396 SOD2 12 Japan 806
Adenocarcinoma 0.363 TP53 11 China 799
Ovarian neoplasms 0.331 STAT3 10 United Kingdom 674
Prostatic neoplasms 0.329 CCND1 10 Germany 620
Lung neoplasms 0.329 ESR1 10 France 486
Stomach neoplasms 0.321 KRAS 9 Canada 433
Cholangiocarcinoma 0.308 TNF 9 South Korea 347
Glioma 0.306 TNFSF10 9 Spain 329
ESR1 Breast neoplasms 0.423 SOD2 14 United States 5429
Alzheimer disease 0.358 EGFR 13 United Kingdom 1249
Neoplasm metastasis 0.345 PTGS2 12 Japan 918
Carcinoma 0.344 TNF 11 China 764
Coronary artery disease 0.342 CDH1 10 Italy 727
Migraine disorders 0.333 ACE 10 France 569
Obesity 0.327 ERBB2 10 Germany 517
Leiomyoma 0.327 PTEN 9 Canada 515
Myocardial infarction 0.323 STAT3 9 South Korea 338
Infertility, male 0.321 TP53 9 Sweden 299
PGR Breast neoplasms 0.38 EGFR 7 United States 1887
Endometriosis 0.346 ESR1 6 Japan 456
Carcinoma 0.32 ESR2 6 Italy 404
Meningioma 0.307 STAT3 5 China 385
Adenocarcinoma 0.304 EFEMP1 5 United Kingdom 311
Mammary neoplasms, animal 0.3 CDH1 5 France 294
Mammary neoplasms, experimental 0.3 PHB 5 Germany 245
Mesothelioma 0.3 PDGFA 5 Canada 188
Recurrence 0.3 STAT5A 5 South Korea 169
Malignant neoplasm breast 0.126 ENO1 5 Sweden 131
EGF Hypomagnesemia 4, renal 0.6 SOD2 11 United States 2199
Wounds and injuries 0.4 IL6 9 United Kingdom 408
Breast neoplasms 0.325 MMP9 9 Japan 394
Prostatic neoplasms 0.322 PTGS2 9 China 378
Carcinoma, hepatocellular 0.317 TNF 9 Italy 298
Neoplasm metastasis 0.315 PTEN 8 Germany 239
Glioblastoma 0.311 EGFR 8 South Korea 211
Adenocarcinoma 0.307 IGF1 8 Canada 205
Kidney diseases 0.301 IL8 8 France 173
Stomach ulcer 0.3 TGFB1 7 Spain 112
BRCA1 Breast-ovarian cancer, familial, Susceptibility To, 1 0.7 CDH1 7 United States 1845
Malignant neoplasm breast 0.54 CCND1 7 United Kingdom 395
Malignant neoplasm of ovary 0.44 SOD2 7 Canada 304
Breast neoplasms 0.419 BRCA2 6 France 222
Mammary neoplasms, experimental 0.4 HRAS 6 The Netherlands 218
Ovarian neoplasms 0.381 STAT3 6 Italy 197
Neoplasms 0.375 EGFR 6 China 182
Carcinoma 0.366 ERBB2 6 Spain 143
Hereditary breast and ovarian cancer Syndrome 0.359 ESR1 6 Germany 140
Prostatic neoplasms 0.318 AKT1 5 Japan 124
BRCA2 Fanconi anemia, complementation Group D1 0.7 BRCA1 6 United States 885
Malignant neoplasm breast 0.54 CTNNB1 6 United kingdom 256
Ovarian neoplasms 0.464 ERBB2 6 Canada 203
Prostatic neoplasms 0.409 PTEN 5 Italy 119
Medulloblastoma 0.401 SOD2 5 The Netherlands 115
Breast neoplasms 0.392 TNF 5 Germany 102
Hereditary breast and ovarian cancer Syndrome 0.334 TNFSF10 5 France 100
Fanconi ANEMIA 0.326 AKT1 4 Spain 93
Pancreatic neoplasms 0.309 BRIP1 4 Australia 73
Wilms tumor 0.3 CDH1 4 Israel 70
CDKN2A Melanoma-pancreatic cancer syndrome 0.6 TP53 15 United States 1809
Melanoma, cutaneous malignant, susceptibility To, 2 0.6 SOD2 12 China 431
Lung neoplasms 0.442 KRAS 9 Japan 340
Stomach neoplasms 0.411 PTGS2 9 United Kingdom 325
Esophageal neoplasms 0.41 ABCB1 7 Italy 297
Neoplasms 0.391 CSF3 7 France 224
Adenocarcinoma 0.358 EGFR 7 Germany 218
Glioma 0.341 ESR1 6 South Korea 202
Precursor cell lymphoblastic leukemia-Lymphoma 0.338 MET 6 Canada 186
Carcinoma, non-small-cell lung 0.332 ERBB2 6 Spain 136
ALPPL2 Abortion, spontaneous 0.3 CEACAM1 1 United States 104
Parkinson disease 0.003 HSD17B1 1 Germany 32
Stroke 0.003 IFI35 1 United Kingdom 30
Carcinoma in situ 0.001 IFI44 1 Italy 28
Seminoma 0.001 IFI6 1 France 18
Retinal diseases <0.001 IFNA10 1 Japan 16
Embryonal neoplasm <0.001 IGFBP1 1 Canada 13
Carcinoma, embryonal <0.001 IGFBP6 1 Greece 11
IL11 1 The Netherlands 9
IL12B 1 China 9
CD99 Chondrosarcoma, mesenchymal 0.3 PDGFRA 1 United States 342
Neuroectodermal tumors, primitive, Peripheral 0.012 BCL2 1 Japan 77
Sarcoma, ewing 0.01 IL1A 1 Germany 74
Breast neoplasms 0.005 MKI67 1 Italy 63
Carcinoma 0.005 China 56
Neuroectodermal tumors, primitive 0.004 United Kingdom 52
Osteosarcoma 0.003 Canada 37
Neoplasms 0.003 France 26
Lymphoma 0.003 Australia 24
Adenocarcinoma 0.003 The Netherlands 22
CHI3L1 Schizophrenia 0.319 TNF 3 United States 90
Glioblastoma 0.311 MET 3 Japan 17
Glioma 0.31 MGMT 2 United Kingdom 17
Neoplasm invasiveness 0.303 TGM2 2 Italy 15
Osteoarthritis 0.301 ACO1 2 France 12
Asthma-related traits, susceptibility To, 7 0.3 MMP9 2 Denmark 10
Hypertension 0.103 GDNF 2 Germany 6
Asthma 0.017 FTL 2 Australia 6
Arthritis, rheumatoid 0.009 ENO1 2 Finland 5
Neoplasm malignant 0.005 EGF 2 India 5
SOD1 Amyotrophic lateral sclerosis 1 0.66 TNF 19 United States 265
Amyotrophic lateral sclerosis 0.551 SOD2 17 Italy 42
Hypertension 0.402 IL6 15 Japan 40
Deficiency diseases 0.4 PTGS2 14 India 39
Motor neuron disease 0.341 NOS2 13 China 31
Down syndrome 0.323 CAT 13 United Kingdom 28
Atherosclerosis 0.31 AGT 11 Germany 26
Diabetes mellitus, type 2 0.31 IL1B 10 The Netherlands 25
Ischemia 0.309 IFNG 10 Turkey 20
Parkinson disease 0.309 ALB 10 Canada 18
AMN Imerslund-grasbeck syndrome 0.601 TNF 3 United States 138
Acute kidney injury 0.3 KNG1 3 United Kingdom 32
Neurogenic inflammation 0.3 TAC1 3 Germany 22
Edema 0.3 IL6 2 Japan 18
Extravasation of diagnostic and Therapeutic Materials 0.3 POMC 2 China 16
anemia, megaloblastic 0.003 CALCA 2 Canada 12
adrenoleukodystrophy 0.003 PTGS2 2 France 10
Nervous system malformations 0.003 INS 2 Italy 9
Malabsorption syndromes 0.001 KLK1 1 The Netherlands 9
Adrenomyeloneuropathy <0.001 LCN2 1 Australia 7
CD40LG Hyper-igm immunodeficiency syndrome, Type 1 0.629 CCL2 4 United States 66
Coronary artery disease 0.306 IL1B 3 Germany 15
Pneumonia 0.3 IL6 3 United Kingdom 12
Amyotrophic lateral sclerosis 0.3 TNF 3 Japan 11
Hypersensitivity 0.3 IL8 3 Italy 10
Necrosis 0.3 IFNG 3 Argentina 9
Hypertension, pulmonary 0.3 IL5RA 2 China 9
Diabetes mellitus, type 1 0.101 HMOX1 2 Australia 7
Enterocolitis, necrotizing 0.1 IL13 2 Denmark 6
Periodontal diseases 0.1 IL17A 2 The Netherlands 6
CD79A Agammaglobulinemia 0.3 BTK 1 United States 22
Leukemia, lymphocytic, chronic, B Cell 0.003 CD19 1 France 8
Lymphoma, non-hodgkin 0.003 IGLL1 1 China 7
Lymphoma, B-cell 0.003 LRRC8A 1 Japan 6
Leukemia, myeloid, acute 0.003 India 4
Leukemia 0.003 Spain 4
Multiple myeloma 0.003 Sweden 3
Lymphoma <0.001 Belgium 3
Takayasu arteritis <0.001 Finland 3
Lymphoma, large B-Cell, diffuse <0.001 United Kingdom 3
PRL Prolactinoma 0.415 DRD2 9 United States 294
Hyperprolactinemia 0.412 POMC 8 United Kingdom 59
Adenoma 0.33 IL6 6 Italy 55
Lupus erythematosus, systemic 0.325 CYP19A1 6 Canada 40
Pituitary neoplasms 0.311 TNF 6 France 31
Autistic disorder 0.304 ESR2 5 Australia 29
Growth hormone-secreting pituitary Adenoma 0.302 AGT 5 Japan 28
Endometriosis 0.301 CNR1 5 China 23
Hypopituitarism 0.301 CRH 5 Spain 20
Amenorrhea 0.301 CYP17A1 5 India 19
AFP Carcinoma, hepatocellular 0.398 MMP9 5 United States 46
Liver diseases 0.303 HMOX1 4 Japan 12
Liver cirrhosis, experimental 0.3 ENO1 3 China 11
Breast neoplasms 0.3 MMP2 3 Germany 8
Mammary neoplasms, experimental 0.3 ESR1 3 Italy 7
Liver neoplasms 0.019 HRAS 3 France 6
Recurrent malignant neoplasm 0.015 NOS2 3 Canada 5
Hepatitis B 0.014 IGF1 3 Ireland 4
Neoplasm malignant 0.012 PTGS2 3 Turkey 3
Down syndrome 0.011 TNFSF10 3 Singapore 3
POMC Obesity 0.454 TNF 22 United States 27
Proopiomelanocortin deficiency 0.4 IL6 17 Italy 10
Cushing syndrome 0.331 AGT 15 Japan 9
Pituitary acth hypersecretion 0.315 IL1B 15 France 7
Adrenal cortex diseases 0.309 PTGS2 15 United kingdom 6
Acth syndrome, ectopic 0.306 SOD2 14 Spain 5
Heart failure 0.304 ALB 12 The netherlands 5
Spasms, infantile 0.303 INS 12 Germany 4
Hypertension 0.303 BDNF 11 Austria 4
Osteoporosis 0.303 CRH 11 Poland 4