Skip to main content

Table 3 SuperPaths overrepresented among genes downregulated in the inner cell mass by CSF2

From: Regulation of gene expression in the bovine blastocyst by colony stimulating factor 2

ERK signaling (score = 22.99)—51 genes

 ACTA2, ACTG2, ADCY8, ALK, ARHGDIB, ARHGEF6, CACNB3, CACNA1G, CCL5, CDH2, CDH9, COL1A1, DES, EFEMP1, EPHA3, ESR2, FGF16, FOSB, FOSL1, GNA11, GNA12, GNAT2, IL11RA, IL12RB2, IL15RA, IL20, IL4, IL7, IRAK1, LEF1, MAPK12, MYH1, MYLPF, MYO18B, MYO7A, MUC1, MYC, NCAN, PAK3, PPP1R3C, SEMA4G, SMAD9, SOX11, SOX30, STAT6, TGFBR3, TIMP2, TNFAIP6, TNFSF9, TNFSF11, VIM

Integrin pathway (score = 16.42)—28 genes

 ACTA2, ACTG2, ADCY8, ARHGEF6, CACNA1G, CACNB3, CAV1, CCL5, CLDN1, COL1A1, EFEMP1, GNA11, GNA12, GNAT2, MAPK13, MMP9, MYC, MYH1, MYLPF, MYO18B, MYO7A, NCAN, NOX1, PAK3, STAT6, TGFBR3, THBS1, VAV3

Visual cycle (score = 14.74)—10 genes

 GNA11, GNA12, GNAT2, GUCA1A, GUCY2C, LRAT, PDE6A, RDH10, RDH12, SLC24A1

Akt signaling (score = 14.45)—30 genes

 ACTA2, ACTG2, AKR1B1, ALK, ATXN7, CCL5, EPHA3, FGF16, FOSL1, GABRG1, GNA11, GNA12, GNAT2, IL11RA, IL12RB2, IL15RA, IL20, IL4, IL7, IRAK1, MAPK13, PAK3, SEMA4G, STAT6, TIMP2, TLR7, TNFAIP6, TNFSF11, TNFSF9, VAV3

  1. Shown are those SuperPaths that were highly significant (P < 0.001). Note that there were no SuperPaths identified in the list of genes upregulated in the ICM by CSF2