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Table 3 SuperPaths overrepresented among genes downregulated in the inner cell mass by CSF2

From: Regulation of gene expression in the bovine blastocyst by colony stimulating factor 2

ERK signaling (score = 22.99)—51 genes
 ACTA2, ACTG2, ADCY8, ALK, ARHGDIB, ARHGEF6, CACNB3, CACNA1G, CCL5, CDH2, CDH9, COL1A1, DES, EFEMP1, EPHA3, ESR2, FGF16, FOSB, FOSL1, GNA11, GNA12, GNAT2, IL11RA, IL12RB2, IL15RA, IL20, IL4, IL7, IRAK1, LEF1, MAPK12, MYH1, MYLPF, MYO18B, MYO7A, MUC1, MYC, NCAN, PAK3, PPP1R3C, SEMA4G, SMAD9, SOX11, SOX30, STAT6, TGFBR3, TIMP2, TNFAIP6, TNFSF9, TNFSF11, VIM
Integrin pathway (score = 16.42)—28 genes
 ACTA2, ACTG2, ADCY8, ARHGEF6, CACNA1G, CACNB3, CAV1, CCL5, CLDN1, COL1A1, EFEMP1, GNA11, GNA12, GNAT2, MAPK13, MMP9, MYC, MYH1, MYLPF, MYO18B, MYO7A, NCAN, NOX1, PAK3, STAT6, TGFBR3, THBS1, VAV3
Visual cycle (score = 14.74)—10 genes
 GNA11, GNA12, GNAT2, GUCA1A, GUCY2C, LRAT, PDE6A, RDH10, RDH12, SLC24A1
Akt signaling (score = 14.45)—30 genes
 ACTA2, ACTG2, AKR1B1, ALK, ATXN7, CCL5, EPHA3, FGF16, FOSL1, GABRG1, GNA11, GNA12, GNAT2, IL11RA, IL12RB2, IL15RA, IL20, IL4, IL7, IRAK1, MAPK13, PAK3, SEMA4G, STAT6, TIMP2, TLR7, TNFAIP6, TNFSF11, TNFSF9, VAV3
  1. Shown are those SuperPaths that were highly significant (P < 0.001). Note that there were no SuperPaths identified in the list of genes upregulated in the ICM by CSF2