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Table 5 SuperPaths overrepresented among genes downregulated in the trophectoderm by CSF2

From: Regulation of gene expression in the bovine blastocyst by colony stimulating factor 2

CREB Pathway (score = 17.43)—22 genes
 ARHGEF6, AXL, BMP3, CACNA2D3, CACNG6, CLU, EPHA3, EPHB3, FLT1, FLT3, GNA14, GNB5, GNRH1, GRID2, HTR3E, PDE1C, PRKCH, SEMA5A, SLC8A2, TEK, THPO, VAV3
Actin Nucleation by ARP-WASP Complex (score = 14.94)—16 genes
 ARHGEF6, AXL, EPHA3, EPHB3, FLT1, FLT3, GNA14, GNB5, ITGAE, ITGB6, LPAR1, LPAR3, MYH1, MYH7, MYO7A, TEK
Akt Signaling (score = 14.53)—24 genes
 AXL, BMP15, BMP3, CCL17, CD28, CD80, EPHA3, EPHB3, FCER1G, FLT1, FLT3, GNA14, GNB5, GNRH1, IL10, ITGAE, ITGB6, PRKCH, PXDN, SEMA5A, TEK, THPO, TNFSF8, VAV3
ERK Signaling (score = 14.11)—34 genes
 ARHGEF6, AXL, BMP15, BMP3, CACNA2D3, CACNG6, CCL17, CD28, CD80, CDH13, ECM2, EPHA3, EPHB3, FBN1, FLT1, FLT3, GNA14, GNB5, GNRH1, IL10, ITGAE, ITGB6, LAMA4, MUC1, MYC, MYH1, MYH7, MYO7A, PRKCH, PXDN, SEMA5A, TEK, THPO, TNFSF8
TGF-BETA (score = 11.30) 21 genes
 ARHGEF6, AXL, BMP15, BMP3, CCL17, CD80, EPHA3, EPHB3, FLT1, FLT3, GNA14, GNB5, GNRH1, IL10, ITGAE, ITGB6, MYC, PXDN, SEMA5A, TEK, THPO
Nanog in mammalian ESC pluripotency (score = 9.82)—17 genes
 AQP2, AXL, BMP3, CDH13, EPHA3, EPHB3, FLT1, FLT3, GNB5, GNRH1, LPAR1, LPAR3, PRKCH, SEMA5A, TEK, THPO, WNT8B
  1. Shown are those SuperPaths that were highly significant (P < 0.001) as well as two selected pathways that were P < 0.05 (TGF-BETA and Nanog in Mammalian ESC pluripotency)