Table 5 SuperPaths overrepresented among genes downregulated in the trophectoderm by CSF2

CREB Pathway (score = 17.43)—22 genes

 ARHGEF6, AXL, BMP3, CACNA2D3, CACNG6, CLU, EPHA3, EPHB3, FLT1, FLT3, GNA14, GNB5, GNRH1, GRID2, HTR3E, PDE1C, PRKCH, SEMA5A, SLC8A2, TEK, THPO, VAV3

Actin Nucleation by ARP-WASP Complex (score = 14.94)—16 genes

 ARHGEF6, AXL, EPHA3, EPHB3, FLT1, FLT3, GNA14, GNB5, ITGAE, ITGB6, LPAR1, LPAR3, MYH1, MYH7, MYO7A, TEK

Akt Signaling (score = 14.53)—24 genes

 AXL, BMP15, BMP3, CCL17, CD28, CD80, EPHA3, EPHB3, FCER1G, FLT1, FLT3, GNA14, GNB5, GNRH1, IL10, ITGAE, ITGB6, PRKCH, PXDN, SEMA5A, TEK, THPO, TNFSF8, VAV3

ERK Signaling (score = 14.11)—34 genes

 ARHGEF6, AXL, BMP15, BMP3, CACNA2D3, CACNG6, CCL17, CD28, CD80, CDH13, ECM2, EPHA3, EPHB3, FBN1, FLT1, FLT3, GNA14, GNB5, GNRH1, IL10, ITGAE, ITGB6, LAMA4, MUC1, MYC, MYH1, MYH7, MYO7A, PRKCH, PXDN, SEMA5A, TEK, THPO, TNFSF8

TGF-BETA (score = 11.30) 21 genes

 ARHGEF6, AXL, BMP15, BMP3, CCL17, CD80, EPHA3, EPHB3, FLT1, FLT3, GNA14, GNB5, GNRH1, IL10, ITGAE, ITGB6, MYC, PXDN, SEMA5A, TEK, THPO

Nanog in mammalian ESC pluripotency (score = 9.82)—17 genes

 AQP2, AXL, BMP3, CDH13, EPHA3, EPHB3, FLT1, FLT3, GNB5, GNRH1, LPAR1, LPAR3, PRKCH, SEMA5A, TEK, THPO, WNT8B