|
Gene
|
Mutation
|
Manifestation, age at diagnosis
|
Family history
|
|---|
|
BRCA1
|
c.181T > G
|
BC, 34 years
|
Mother, BC 45 years
|
| |
c.798-799delTT
|
BC, 42 years
|
Mother, BOC 50 years
|
| | | |
M Cousin, BC 47 years
|
| |
c.2805delA
|
BC, 41 years
|
M aunt, BC 42 years
|
| |
c.3279delC
|
BC, 32 years
|
Mother, BC 49 years
|
| |
c.3279delC
|
BC, 49 years
|
Daughter, BC 32 years
|
| |
c.5062-5064delGTT
|
BC, 25 years
|
M aunt, CS 40 years
|
| | | |
M cousin, BC 27 years
|
|
BRCA2
|
c.745-1G > A
|
BC, 33 years
|
No family history
|
| |
c.3381delT
|
BC, 38 years
|
Mother, BC 50 years
|
| |
c.7110delA
|
BC, 38 years
|
M aunt, BC 43 years
|
| | | |
Mother, BC 40 years
|
| |
c.7235insG
|
BC, 40 years
|
M aunt, BC 38 years
|
| | | |
M aunt, BC 42 years
|
| | | |
M aunt, BC 45 years
|
| | | |
Sister, BC 33 years
|
| |
c.7235insG
|
BBC, 45 years
|
Sister, BC 41 years
|
| | | |
P cousin, BC 40 years
|
| | | |
P cousin, BC 50 years
|
-
BC breast cancer, BBC bilateral breast cancer, BOC breast and ovarian cancers, M maternal, P paternal
