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Table 1 Comparing GS-EFNS and LDT for assessing nerve fiber density in skin biopsies of healthy volunteers

From: Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?

 

GS-EFNS

LDT

Mean diff

P

IENF (#/mm)

11.47 ± 2.67

5.65 ± 1.93

5.8

<0.001

 IENF_Si (#/mm)

4.45 ± 1.06

4.31 ± 1.59

0.1

0.95

 IENF_Br (#/mm)

7.02 ± 2.23

1.34 ± 0.51

5.7

<0.001

 Sec branching (#/IENF_Br)

3.17 ± 0.26

2.39 ± 0.40

 

<0.001

 Sec branching (#/mm)

22.04 ± 7.92

3.56 ± 1.44

18.5

<0.001

IENF_F (#/mm)

3.98 ± 2.25

6.77 ± 2.89

−2.8

0.01

 IENF_FSi (#/mm)

2.36 ± 1.10

4.86 ± 2.18

−2.5

0.002

 IENF_FBr (#/mm)

1.62 ± 1.28

1.91 ± 0.86

−0.3

0.36

 Sec branching (#/IENF_FBr)

2.52 ± 0.57

2.13 ± 0.23

 

0.04

 Sec branching (#/mm)

4.42 ± 3.91

4.26 ± 1.88

 

0.01

Total ENF (#/mm)

15.45 ± 4.43

12.45 ± 4.33

3.0

0.24

  1. ENF epidermal nerve fiber, GS-EFNS gold standard method according to EFNS; IENF intra-epidermal nerve fiber, IENF_Si intra-epidermal nerve fiber crossing dermal-epidermal junction as single fiber, IENF_Br intra-epidermal nerve fiber crossing dermal-epidermal junction as fiber showing branching, IENF_F nerve fiber fragment lying free in epidermis, IENF_FSi nerve fiber fragment lying free in epidermis as single fragment, IENF_FBr nerve fiber fragment lying free in epidermis showing branching, LDT laboratory developed test, Sec secondary