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Table 1 Comparing GS-EFNS and LDT for assessing nerve fiber density in skin biopsies of healthy volunteers

From: Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?

  GS-EFNS LDT Mean diff P
IENF (#/mm) 11.47 ± 2.67 5.65 ± 1.93 5.8 <0.001
 IENF_Si (#/mm) 4.45 ± 1.06 4.31 ± 1.59 0.1 0.95
 IENF_Br (#/mm) 7.02 ± 2.23 1.34 ± 0.51 5.7 <0.001
 Sec branching (#/IENF_Br) 3.17 ± 0.26 2.39 ± 0.40   <0.001
 Sec branching (#/mm) 22.04 ± 7.92 3.56 ± 1.44 18.5 <0.001
IENF_F (#/mm) 3.98 ± 2.25 6.77 ± 2.89 −2.8 0.01
 IENF_FSi (#/mm) 2.36 ± 1.10 4.86 ± 2.18 −2.5 0.002
 IENF_FBr (#/mm) 1.62 ± 1.28 1.91 ± 0.86 −0.3 0.36
 Sec branching (#/IENF_FBr) 2.52 ± 0.57 2.13 ± 0.23   0.04
 Sec branching (#/mm) 4.42 ± 3.91 4.26 ± 1.88   0.01
Total ENF (#/mm) 15.45 ± 4.43 12.45 ± 4.33 3.0 0.24
  1. ENF epidermal nerve fiber, GS-EFNS gold standard method according to EFNS; IENF intra-epidermal nerve fiber, IENF_Si intra-epidermal nerve fiber crossing dermal-epidermal junction as single fiber, IENF_Br intra-epidermal nerve fiber crossing dermal-epidermal junction as fiber showing branching, IENF_F nerve fiber fragment lying free in epidermis, IENF_FSi nerve fiber fragment lying free in epidermis as single fragment, IENF_FBr nerve fiber fragment lying free in epidermis showing branching, LDT laboratory developed test, Sec secondary