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Table 1 Associations between maternal B-Pb and birth outcomes modelled with adjusted multivariable fractional polynomial models in ALSPAC

From: Low level lead exposure and pregnancy outcomes in an observational birth cohort study: dose–response relationships

  n Unstandardised B regression coefficient (95 % confidence interval) Fit in adjusted mfp model (final powers)a
Adjusted model
 Birthweight (g) 3096 −9.93 (−20.27, 0.41) 1
 Head circumference (cm) 2741 −0.03 (−0.06, 0.00) 1
 Crown–heel length (cm) 2706 −0.05 (−0.10, 0.00) 1
Adjusted model with exclusion of values >10 µg/dl
 Birthweight (g) 3084 −11.07 (−22.12, 0.18) 1
 Head circumference (cm) 2732 −0.04 (−0.07, 0.00) 1
 Crown-heel length (cm) 2697 −0.06 (−0.11, 0.00) 1
Adjusted model for sensitivity analysisb
 Birthweight (g) 2785 −8.16 (−18.97, 2.65) 1
 Head circumference (cm) 2466 −0.04 (−0.08, 0.01) 1
 Crown–heel length (cm) 2436 −0.08 (−0.15, 0.00) 1
  1. mfp multivariable fractional polynomial
  2. aAdjusted for maternal educational attainment, smoking, gestational age (centred at 40 weeks), maternal height and pre-pregnancy weight, and sex of the infant. 1, linear
  3. bExclusion of upper and lower 5 % of B-Pb values