Fig. 1
From: Clinical heterogeneity of PLA2G6-related Parkinsonism: analysis of two Saudi families
p.R741Q mutation of PLA2G6 detected in two families with early-onset parkinsonism. a Chromatogram of the c.2222G > A mutation. b, c Pedigrees of the two families showing the genotypes of the mutation. b Pedigree of family 66 (FM 66). c Pedigree of family 97 (FM 97). d–g Example radiological imaging of the affected individuals. d, f Axial brain fluid attenuated inversion recovery (FLAIR) MRI sequence of the frontotemporal region of 66-E (d) and 66-K (f) showing moderate (d) and mild (f) atrophy. e 18-FDG-PET scan of 66-E showing moderate decrease in glucose uptake in the frontoparietal regions. g Coronal FLAIR MRI sequence showing moderate frontotemporal atrophy of 97-E. * denotes no DNA sample available. AAE age at examination in years; AAO age at onset in years