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Table 5 Hemolytic activity of the most potent antimicrobial lipids

From: Assessment of free fatty acids and cholesteryl esters delivered in liposomes as novel class of antibiotic

Liposomal formulation Hemolysis (% maximal hemolysis) at 900 μg/mL At 90 μg/mLa
30 min 3 h 24 h 30 min 3 h 24 h
PA4 >40 >40 >40 1.61 ± 0.50 3.10 ± 1.00 70.43
SA4 >40 >40 >40 2.21 ± 1.80 4.04 ± 0.60 46.35
CL3 <20 >40 >40 1.13 ± 0.20 0.80 ± 0.10 54.55
  1. Hemolysis was screened at 900 μg/mL lipid concentration and further tested at 90 μg/mL lipid concentration (mean ± S.D., n = 3 for 30 min and 3 h time points and n = 1 for 24 h time point). PA4 palmitic acid prepared in carrier-4, SA4 stearic acid prepared in carrier-4, CL3 cholesteryl linoleate prepared in carrier-3
  2. aThere were no statistically significant differences compared to control erythrocytes after 30 min and 3 h
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