n | Events | Crude | Adjusted | |||||
---|---|---|---|---|---|---|---|---|
Hazard ratio | 95 % CI | p | Hazard ratio | 95 % CI | p | |||
Age | ||||||||
16–22 yearsa | 683 | 50 | ||||||
23–27 years | 437 | 54 | 1.7 | 1.2–2.5 | 0.005 | 1.1 | 0.74–1.7 | 0.62 |
Sex | ||||||||
Femalesa | 518 | 37 | ||||||
Males | 602 | 67 | 1.6 | 1.1–2.4 | 0.021 | 1.2 | 0.76–1.8 | 0.50 |
Main toxic agent | ||||||||
Ethanola | 715 | 27 | ||||||
Opioids | 170 | 48 | 9.2 | 5.7–14.8 | <0.001 | 8.5 | 5.0–14.3 | <0.001 |
Benzodiazepines | 89 | 12 | 3.9 | 2.0–7.7 | <0.001 | 3.8 | 1.8–7.8 | <0.001 |
Central stimulants | 49 | 6 | 3.5 | 1.4–8.5 | 0.006 | 3.2 | 1.3–8.0 | 0.012 |
GHB | 60 | 8 | 3.7 | 1.7–8.1 | 0.001 | 3.4 | 1.5–7.9 | 0.004 |
Other | 37 | 3 | 2.2 | 0.66 -7.1 | 0.20 | 2.1 | 0.63–6.9 | 0.23 |
Referral to follow-up | ||||||||
No referrala | 709 | 55 | ||||||
Referral | 411 | 49 | 2.0 | 1.4–2.9 | <0.001 | 1.0 | 0.69–1.6 | 0.83 |