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Fig. 8 | BMC Research Notes

Fig. 8

From: A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells

Fig. 8

Possible hit compound signaling pathways involved in OL differentiation and myelination. The 27 compounds identified from the acute OL differentiation screen were grouped into seven classes: muscarinic receptor antagonists, andrenergic agonists, tricyclic antidepressants, non-tricyclic antidepressants, selective estrogen receptor modulators (SERMs), ion channel modulators and antifungals. Based on a literature review, these compound classes were further categorized into the most likely steps in OL development where compounds may be active. Note that some of the tricyclic antidepressents and non-tricyclic antidepressents have off-target muscarinic activity. Also note that the OL differentiation-promoting mechanisms of these compounds may not necessarily act through the same mechanisms as the known FDA-approved indication target

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