Fig. 8From: A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cellsPossible hit compound signaling pathways involved in OL differentiation and myelination. The 27 compounds identified from the acute OL differentiation screen were grouped into seven classes: muscarinic receptor antagonists, andrenergic agonists, tricyclic antidepressants, non-tricyclic antidepressants, selective estrogen receptor modulators (SERMs), ion channel modulators and antifungals. Based on a literature review, these compound classes were further categorized into the most likely steps in OL development where compounds may be active. Note that some of the tricyclic antidepressents and non-tricyclic antidepressents have off-target muscarinic activity. Also note that the OL differentiation-promoting mechanisms of these compounds may not necessarily act through the same mechanisms as the known FDA-approved indication targetBack to article page