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Table 1 Confirmed acute OL differentiation hits from the NCC library screen

From: A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells

Drug class

Compound

OL differentiationa

EC50, μM

SERM

Raloxifene

82

0.1

Toremifene

96

0.1

Tamoxifen

85

0.2

Tricyclic anti-depressants

Perphenazine

59

0.1

Fluphenazine

91

0.1

Prochlorperazine

80

0.1

Trifluoperazine

60

0.2

Quetiapine

109

0.4

Non-tricyclic anti-depressants

Perospirone

88

0.1

Nitalapram

51

1.1

Escitalopram

84

1.3

Metylperon

64

7.3

Muscarinic

Benztropine

66

0.3

Donepezil

142

0.5

Vesamicol

91

1.4

Oxybutynin

67

2.6

Ipatropium

58

8.5

Clemastineb

ND

0.2

Adrenergic

Salmeterol

52

0.4

Betaxolol

86

4.2

Esmolol

65

240

Ion-channel

Ifenprodil

93

0.4

Benproperine

82

0.8

Proxymetacaine

77

1.0

Dofetilide

77

14

DMPP

97

13

Anti-fungal

Bifonazole

66

1.7

  1. ND no data. DMPP dimethylphenylpiperazinium
  2. aValues indicate percent positive control
  3. bNot part of the NCC library screen