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Table 3 Comparison of acute OL differentiation hits in the NCC library with hits reported in other OL differentiation assays

From: A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells

Confirmed NCC library hits OL differentiation assays
Drug class Compound MRF-TMCa Deshmukh [3] Mei [6] Najm [7]
SERM Raloxifene    
Toremifene    
Tamoxifen   
Tricyclic anti-depressants Perphenazine   
Fluphenazine   
Prochlorperazine    
Trifluoperazine   
Quetiapine  
Non-tricyclic anti-depressants Perospirone    
Nitalapram    
Escitalopram    
Metylperon    
Muscarinic Benztropine
Donepezil    
Vesamicol   
Oxybutynin  
Ipatropium  
Clemastineb  
Adrenergic Salmeterol   
Betaxolol    
Esmolol    
Ion-channel Ifenprodil    
Benproperine    
Proxymetacaine    
Dofetilide    
DMPP    
Anti-fungal Bifonazole    
  1. aMyelin Repair Foundation, Translation Medicine Center
  2. bCompound not part of the NCC library screen