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Table 3 Comparison of acute OL differentiation hits in the NCC library with hits reported in other OL differentiation assays

From: A high throughput drug screening assay to identify compounds that promote oligodendrocyte differentiation using acutely dissociated and purified oligodendrocyte precursor cells

Confirmed NCC library hits

OL differentiation assays

Drug class

Compound

MRF-TMCa

Deshmukh [3]

Mei [6]

Najm [7]

SERM

Raloxifene

   

Toremifene

   

Tamoxifen

  

Tricyclic anti-depressants

Perphenazine

  

Fluphenazine

  

Prochlorperazine

   

Trifluoperazine

  

Quetiapine

 

Non-tricyclic anti-depressants

Perospirone

   

Nitalapram

   

Escitalopram

   

Metylperon

   

Muscarinic

Benztropine

Donepezil

   

Vesamicol

  

Oxybutynin

 

Ipatropium

 

Clemastineb

 

Adrenergic

Salmeterol

  

Betaxolol

   

Esmolol

   

Ion-channel

Ifenprodil

   

Benproperine

   

Proxymetacaine

   

Dofetilide

   

DMPP

   

Anti-fungal

Bifonazole

   
  1. aMyelin Repair Foundation, Translation Medicine Center
  2. bCompound not part of the NCC library screen