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Table 4 Frequency and severity of side effects among current users

From: The real-world patient experience of fingolimod and dimethyl fumarate for multiple sclerosis

Side effect Ever experienced while on current medication, N (%) Experienced in last 7 days, N (%) Mean number of days experienced in last 7 days, mean (SD) Mean severity rating in last 7 days, mean (SD) (1–10 scale)a
CF (N = 61) CDMF (N = 129) Current fingolimod (CF) ever experienced side effect while on current medication Current dimethyl fumarate (CDMF) ever experienced side effect while on current medication Current fingolimod (CF) experienced side effect in last 7 days Current dimethyl fumarate (CDMF) experienced side effect in last 7 days Current fingolimod (CF) experienced side effect in last 7 days Current dimethyl fumarate (CDMF) experienced side effect in last 7 days
Abdominal pain 2 (3.3 %) 48 (37.2 %) 1/2 (50.0 %) 18/48 (37.5 %) 7.0 (NA) n = 1 3.3 (2.1) n = 18 4.0 (NA) n = 1 4.8 (2.0) n = 18
Back pain 5 (8.2 %) 11 (8.5 %) 2/5(40.0 %) 4/11 (36.4 %) 5.0 (2.8) n = 2 6.5 (1.0) n = 4 5.0 (0.0) n = 2 5.8 (2.8) n = 4
Cough 6 (9.8 %) 17 (13.2 %) 3/6 (50.0 %) 11/17 (64.7 %) 5.7 (1.2) n = 3 4.9 (2.3) n = 11 3.3 (2.1) n = 3 4.3 (1.8) n = 11
Diarrhea 10 (16.4 %) 40 (31.0 %) 4/10 (40.0 %) 16/40 (40.0 %) 4.3 (2.2) n = 4 3.8 (1.9) n = 16 5.8 (1.9) n = 4 5.6 (2.3) n = 16
Flushing 12 (19.7 %) 99 (76.7 %) 6/12 (50.0 %) 54/99 (54.5 %) 4.7 (2.6) n = 6 4.1 (2.3) n = 54 5.2 (1.7) n = 6 5.0 (2.9) n = 54
Headache 18 (29.5 %) 34 (26.4 %) 9/18 (50.0 %) 14/34 (41.2 %) 4.4 (2.1) n = 9 4.5 (2.1) n = 14 5.3 (2.9) n = 9 5.1 (2.6) n = 14
Flu-like symptoms 2 (3.3 %) 15 (11.6 %) 1/2 (50.0 %) 5/15 (33.3 %) 5.0 (NA) n = 1 2.2 (1.3) n = 5 6.0 (NA) n = 1 3.2 (3.2) n = 5
Nausea 8 (13.1 %) 44 (34.1 %) 1/8 (12.5 %) 22/44 (50.0 %) 4.0 (NA) n = 1 2.9 (1.5) n = 22 8.0 (NA) n = 1 4.4 (2.0) n = 1
Vomiting 4 (6.6 %) 11 (8.5 %) 1/4 (25.0 %) 2/11 (18.2 %) 2.0 (NA) n = 1 1.5 (0.7) n = 2 6.0 (NA) n = 1 7.5 (0.7) n = 2
  1. aSeverity rated on a 1–10 scale with 1 being very mild and 10 as bad as one can imagine