Table 2 Antimicrobial activity of representative CS-αβ peptides

Sarcophaga peregrina

Sapecin, Sapecin A [Swiss-Prot: P18313]

6

Yes

G+, G−

[5, 72, 73, 99]

Sapecin B [Swiss-Prot: P31529]

6

No

G+ (G−, Y)

Protophormia terraenovae

Phormicin, defensin A [Swiss-Prot: P10891]

6

Yes

G+, G−, F (Y)

[4, 46, 47]

Apis mellifera

Royalisin [Swiss-Prot: P17722]

6

Yes

G+, G−

[49, 103]

Drosophila melanogaster

Defensin [Swiss-Prot: P36192]

6

Yes

G+

[50]

Drosomycin [Swiss-Prot: P41964]

8

Yes

F, Y, P (G+, G−, H)

[10, 100]

Heliothis virescens

Heliomicin [GenBank: ACR78445]

6

Yes

F, Y (G+, G−)

[46]

Galleria mellonella

Gallerimycin [Swiss-Prot: Q8MVY9]

6

Yes

F (G+, G−, Y)

[52]

Defensin [Swiss-Prot: P85213]

6

Yes

F, Y (G+, G−)

[51]

Ixodes scapularis

Scapularisin (Scapularisin 6) [GenBank: AAV74387]

6

Yes

G+, F (G−)

[53, 104]

Ixodes scapularis

Scapularisin 3 [GenBank: EEC13914]

6

Reverse

F (G+, G−)

[53, 70]

Leiurus quinquestriatus

Charybdotoxin [Swiss-Prot: P13487]

6

Yes

G+, G−, Y

[13, 17, 18]

Leiurus quinquestriatus

Defensin [Swiss-Prot: P41965]

6

Yes

G+ (G−)

[28]

Mytilus galloprovincialis

MGD-1 [Swiss-Prot: P80571]

8

Yes

G+, G−, F (C)

[34, 54, 55, 101]

Mytilus galloprovincialis

Myticin A [Swiss-Prot: P82103]

8

No

G+ (G−, F, P)

[56]

Myticin B [Swiss-Prot: P82102]

8

No

G+, G−, F (P)

Mytilus edulis

Mytilin A [Swiss-Prot: P81612]

8

Yes

G+, G−

[57]

Mytilus galloprovincialis

Mytilin B [GenBank: AAD45013]

8

Yes

G+, G−, F

[58, 105]

Mytilin C [sequence from reference]

7

Yes

G+, G− (F, P)

Mytilin D [GenBank: ACF21701]

8

Reverse?

G+, G−, F

Mytilin G1 [sequence from reference]

8

Yes

G+ (G−, F)

Ascaris suum

ASABF-α [GenBank: BAA89497]

8

Yes

G+, G− (F)

[59]

Caenorhabditis elegans

Ce-ABF2 [NCBI Reference Sequence: NP_491252]

8

Yes

G+, G−, Y

[60]

Suberites domuncula

ASABF-related peptide [GenBank: CCC55928]

8

Yes

G+, G−, F, Y, H

[36]

Caenorhabditis remanei

Cremycin 5 [GenBank: AEM44806]

6

Yes

F, Y (G+, G−, H)

[21]

Cremycin 15 [GenBank: AEM44812]

6

Yes

G+, G− (F, Y)

Hydra magnipapillata

Hydramacin [GenBank: ABE26989]

8

Yes

G+, G−

[40, 41]

Hirudo medicinalis

Neuromacin [Swiss-Prot: A8V0B3]

8

Yes

G+, G−

[40]

Theromacin [Swiss-Prot: A8I0L8]

10

Yes

G+, G−

Theromyzon tessulatum

Theromacin [GenBank: AAR12065]

10

Yes

G+ (G−, F)

[39]

Achatina fulica

Mytimacin-AF [GenBank: AFR36920]

10

Yes

G+, G−, Y (H)

[44]

Raphanus sativus

RsAFP1 [GenBank: AAA69541]

8

Yes

F (G+, G−, Y, C, H)

[8, 61]

Zea mays

Gamma-2-zeathionin, PDC-1 [Swiss-Prot: P81009]

8

Yes

F

[62, 63]

Medicago sativa

MsDEF1 [GenBank: AAG40321]

8

Yes

F

[64–66]

Nicotiana alata

NaD1 [Swiss-Prot: Q8GTM0]

8

Yes

F

[67]

Pentadiplandra brazzeana

Brazzein [Swiss-Prot: P56552]

8

Yes

G+, G−, Y

[13, 68]

Pseudoplectania nigrella

Plectasin [Swiss-Prot: Q53I06]

6

Yes

G+ (G−)

[33]

Arthroderma otae/ Microsporum canis

Micasin [GenBank: JN014007]

6

Yes

G+, G− (F, Y, H)

[24]

Allomyrina dichotoma

Defensin [Swiss-Prot: Q10745]

6

Yes

G+ (G−)

[74]

Oryctes rhinoceros

O. rhinocerus defensin [Swiss-Prot: O96049]

6

Yes

G+

[75]

Copris tripartitus

Coprisin [GenBank: ABP97087]

6

Yes

G+, G−, Y (H, C)

[76, 106, 107]

Tenebrio moliter

Tenecin 1 [Swiss-Prot: Q27023]

6

Yes

G+ (G−, Y)

[69, 108]

Haemaphysalis longicornis

Longicin [Swiss-Prot: Q58A47]

6

Yes

G+, G−, Y, P (H)

[78, 109]

Nasonia vitripennis

Navidefensin 2-2 [Sequence from reference]

6

Yes

G+ (G−, F, Y)

[71]

Homo sapiens

DLD [GenBank: AK024601]

6

No

F (G+, G−, Y)

[80]