Fig. 6

ROI analysis. a ROI 1 Ventricles; b ROI 2 Thalamic nuclei; c ROI 3 Grey matter; d ROI 4 White matter. There exist several techniques and methods of texture analysis. Non-parametric graphs (e.g. histogram, box plot) would be indeed a simple alternative to conduct this study. As shown in the figures, MaZda does display histogram of 8-bit but not for 16-bit DICOM image. Also, there are issues with drawing conclusions straight from histograms and boxplots. They are pictorial representations and thus are indirect methods. Furthermore non-parametric interpretation may not be as precise and accurate as parametric quantification. Therefore, parametric quantification was used to assess image quality rather than conventional appearance. 3D, non-parametric graphs are also possible with collateral usage of MaZda (version 5) and B11 (version 3.3) in training mode. The problem with training methods is that errors might occur as a result of overtraining the network. Hence, raw analysis was performed