Skip to main content

Table 3 Allele and Genotype frequencies (VKORC1, CYP4F2, CYP2C9*2 and CYP2C9*3) of patients administered warfarin at Korle-bu Teaching Hospital in Accra

From: Genetic polymorphisms of patients on stable warfarin maintenance therapy in a Ghanaian population

Genetic characteristic

Frequency,  %

VKORC1 (N = 96)

 Gene

  GG (wild type)

84 (87.5)

  GA

12 (12.5)

  AA

 Allele

  G

180 (93.8)

  A

12 (6.2)

CYP4F2 (N = 116)

 Gene

  CC (wild type)

28 (24.1)

  CT

80 (69.0)

  TT

8 (6.9)

 Allele

  C

136 (58.6)

  T

96 (41.4)

CYP2C9*2 (N = 86)

 Gene

  CC (wild type)

86 (100)

  CT

  TT

 Allele

  C

172 (100)

  T

CYP2C9*3 (N = 84)

 Gene

  AA (wild type)

84 (100)

  AC

  CC

 Allele

  A

168 (100)

  C

  1. CYP2C9, CYP4F2 and VKORC1 were the genes genotyped. CYP2C9*2 and CYP2C9*3 were not detected. Homozygous CYP2C9*1 or heterozygous CYP2C9*1 were considered putative since we did not genotype for the rest of the other allelic variants
  2. N number of study participants, A adenine, G guanine, C cytosine, T thymidine