Skip to main content

Table 3 Allele and Genotype frequencies (VKORC1, CYP4F2, CYP2C9*2 and CYP2C9*3) of patients administered warfarin at Korle-bu Teaching Hospital in Accra

From: Genetic polymorphisms of patients on stable warfarin maintenance therapy in a Ghanaian population

Genetic characteristic Frequency,  %
VKORC1 (N = 96)
 Gene
  GG (wild type) 84 (87.5)
  GA 12 (12.5)
  AA
 Allele
  G 180 (93.8)
  A 12 (6.2)
CYP4F2 (N = 116)
 Gene
  CC (wild type) 28 (24.1)
  CT 80 (69.0)
  TT 8 (6.9)
 Allele
  C 136 (58.6)
  T 96 (41.4)
CYP2C9*2 (N = 86)
 Gene
  CC (wild type) 86 (100)
  CT
  TT
 Allele
  C 172 (100)
  T
CYP2C9*3 (N = 84)
 Gene
  AA (wild type) 84 (100)
  AC
  CC
 Allele
  A 168 (100)
  C
  1. CYP2C9, CYP4F2 and VKORC1 were the genes genotyped. CYP2C9*2 and CYP2C9*3 were not detected. Homozygous CYP2C9*1 or heterozygous CYP2C9*1 were considered putative since we did not genotype for the rest of the other allelic variants
  2. N number of study participants, A adenine, G guanine, C cytosine, T thymidine