Table 2 Drug resistance mutations (DRMs) of participants tested for drug resistance among those with HIV viral loads ≥1000 copies/ml at enrolment, by ARV class
Drug resistance mutation(s) | Proportion with amplified drug resistance tests, n (%) | Proportion with major PI mutations, n (%)1 | Most common mutations2 |
|---|---|---|---|
All | 110 | 7 (6.4) | |
No mutation detected | 8 (7.3) | ||
At least one detected (NRTI, NNRTI, PI) | 102 (92.7) | 7 (6.9) | |
Any NRTI | 92 (83.6) | 6 (6.5) | Non-TAMs: M184V (20.7%), K65R (8.0%) TAMs: M41L (8.0%), K70R (8.0%) |
Any NNRTI | 77 (70.0) | 4 (5.2) | K103N (19.0%), G190A (7.0%), Y181C (6.0%) |
Any PI3 | 33 (30.0) | 7 (21.2) | Major: V82A (7.0%) and I54V, M46I, L33I (all 5.0%) Accessory: L10I (27.0%), L10V (12.0%), L10F(5.0%) |
Mutation to 1 ARV class only (n = 22) | |||
NRTI | 14 (12.7) | 0 (0.0) | |
NNRTI | 7 (6.4) | 0 (0.0) | |
PI | 1 (0.9) | 0 (0.0) | |
Mutation to 2 ARV classes only (n = 60) | |||
NRTI + NNRTI | 48 (43.6) | 0 (0.0) | |
PI + NRTI | 10 (9.1) | 3 (30.0) | |
PI + NNRTI | 2 (1.8) | 1 (50.0) | |
Mutations to 3 ARV classes (n = 20) 4 | 20 (18.2) | 3 (15.0) | |
HIV subtype | |||
A | 37 (33.6) | 3 (8.1) | V82A/S, I54V/U, M46I/L, K43T, L10F, L89V, L24IL |
B | 5 (4.5) | 0 (0.0) | |
C | 6 (5.5) | 0 (0.0) | |
D | 38 (34.5) | 4 (10.5) | V82A/V/F, I54IV, I54V, M46I, L33F, L10I, L10F, L24I, K20T, A71T, Q58E, I47V |
CRF01_AE | 24 (21.8) | 0 (0.0) | |