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Table 2 Predictors of incidence of HSV-2

From: Prevalence of Herpes Simplex Virus 2 (HSV-2) infection and associated risk factors in a cohort of HIV negative women in Durban, South Africa

Variable Univariate analysis Multivariate analysis
Hazard ratio (95% CI) p value Hazard ratio (95% CI) p value
Age*
 <23 1   1  
 23–27 1.18 (0.91–1.54) 0.213 1.21 (0.93–1.58) 0.155
 28–37 1.20 (0.93–1.55) 0.157 1.27 (0.98–1.64) 0.066
 38+ 1.57 (1.23–2.00) <0.001 1.71 (1.34–2.19) <0.001
Employed/income
 Yes 1.03 (0.88–1.30) 0.805   
 No 1    
Religion
 Other 1    
 Christian 1.21 (1.01–1.44) 0.040
Education
 ≥High school 1    
 <High school 1.11 (0.91–1.35) 0.289   
Age at first sex act (years)
 >15  1    
 <15 1.11 (0.76–1.64) 0.586
STI
 C. trachomatis 1.07 (0.80–1.43) 0.663
 N. gonorrhea 0.76 (0.49–1.18) 0.221
 Syphilis 1.23 (0.66–2.31) 0.510
 T. vaginalis 0.97 (0.71–1.32) 0.835
Contraception
 None 1    
 Othera 1.39 (1.08–1.82)) 0.012
 Hormonal 0.86 (0.59–1.25) 0.416
 Condom 0.93 (0.75–1.14) 0.481
Biological factors
 STI (s) baseline 1.04 (0.84–1.29) 0.705
 STI (s) incidence 1.13 (0.90–1.42) 0.314
 HIV incidence 1.71 (1.30–2.24) <0.001 1.84 (1.40–2.42) <0.001
 Pregnancy incidence 1.25 (0.93–1.67) 0.133 1.37 (1.02–1.83) 0.038
  1. CI confidence interval
  2. aIncludes tubal ligation, intrauterine devices and traditional methods
  3. * Median (IQR) = 27 (23–37); p value for rank test was <0.001