Fig. 4
Longitudinal interferon-gamma responses post-prophylactic treatment for latent tuberculosis infection. Longitudinal analysis upon enrollment (T0) and after 1-year follow up (T1) of mean interferon-gamma levels via short- (WBA) and long-term (LSA) stimulation assays with blood specimens from recent close contacts of TSTpos treated for latent tuberculosis infection (Black circle) and stratified according to their baseline interferon-gamma response (non-responders and responders) to each Mycobacterium tuberculosis antigen: a ESAT6:CFP10; b PstS1/CFP10; and c PstS1(285–374):CFP10. *p < 0.05 via Wilcoxon signed rank test. White square recent close contact exposed to a multidrug-resistant Mycobacterium tuberculosis strain