Fig. 1

Change in CAL. a Mean CAL values at each evaluation period. Data shown as mean ± SD (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001, compared to baseline, ^†† P < 0.01, compared to 6 months, by ANOVA with Tukey–Kramer multiple comparisons test. b Distribution of individual CAL change from baseline at 2.5 years. Dotted line indicates the mean value. CAL clinical attachment level