Fig. 1

Structure representation of c-Src in complex with ANP (PDB: 2SRC). a Ribbon representation of the kinase domain of c-Src in complex with ANP [38]. Tyr belonging to the activation segment is represented as stick. b Surface representation of a kinase ligand-binding pocket. The ATP is represented as stick. The five regions belonging to the ATP binding pocket are represented in different colors with the buried region behind the ATP