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Table 1 Liver Cyp2a5 (COH), Cyp1a1/2 (EROD) and Cyp2b9/10 (BROD) activities in different mouse strains. Female mice were treated ip with PBS (CON), pyrazole (PYR 100 mg/kg bw/days × 3 days), or phenobarbital (PB, 80 mg/kg bw/days × 3 days) and euthanized 24-h after the last dose

From: Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver

Treatment Monooxygenase activity (pmoles/mg protein/min)
COH EROD BROD
CON PYR PB CON PYR PB CON PYR PB
Mouse strain
 BALB/cAn 35.2 ± 2.9 69.7 ± 4.4* 75.3 ± 6.0* 71.2 ± 6.0 103.1 ± 9.0 532.7 ± 77.5* 56.6 ± 5.7 53.3 ± 4.0 192.8 ± 23.9*
 CBA 32.9 ± 5.0 119.7 ± 5.2* 91.9 ± 5.4* 74.9 ± 4.9 61.5 ± 5.5 293.0 ± 33.7* 22.0 ± 2.3 19.8 ± 3.5 212.5 ± 22.4*
 C57BL/6 44.5 ± 6.0 112.1 ± 8.4* 62.2 ± 5.5 99.2 ± 7.2 98.7 ± 8.6 444.3 ± 28.6* 47.3 ± 5.8 33.4 ± 4.8 158.9 ± 8.7*
 C57BL/10 24.4 ± 3.8 88.1 ± 4.1* 63.6 ± 5.9* 132.2 ± 9.4 135.5 ± 16.9 598.7 ± 59.5* 42.6 ± 3.5 72.9 ± 29.9 181.3 ± 5.5*
 DBA-1 142.5 ± 28.3 344.8 ± 50.6* 261.8 ± 24.6 50.2 ± 3.3 50.0 ± 4.0 265.7 ± 13.1* 26.8 ± 1.4 43.4 ± 12.4 271.0 ± 2.3*
 DBA-2 228.4 ± 24.8 507.7 ± 12.5* 493.5 ± 11.7* 74.9 ± 7.9 64.3 ± 6.3 338.1 ± 14.8* 39.8 ± 2.8 41.0 ± 3.8 266.9 ± 28.5*
 B6D2F1 113.3 ± 11.6 437.8 ± 24.3* 308.4 ± 20.6* 68.8 ± 3.4 66.6 ± 3.6 251.1 ± 14.1* 35.2 ± 4.1 45.0 ± 5.3 306.5 ± 8.8*
 SW 24.1 ± 5.3 78.5 ± 8.8* 42.5 ± 3.1 72.8 ± 7.6 74.8 ± 9.1 348.5 ± 29.7* 41.2 ± 7.8 38.8 ± 10.2 143.6 ± 4.4*
  1. Values are shown as mean ± SEM. Data were evaluated by ANOVA and Dunnett’s post hoc test. Means that are different (P < 0.05) from respective controls are indicated by an asterisk (*). N = 6 mice of each strain per group (CON, PYR or PB)
  2. COH (coumarin 7-hydroxylase) pmoles umbelliferone/mg protein/min, EROD (ethoxyresorufin-), BROD (benzyloxy-resorufin-O-dealkylase) pmoles resorufin/mg protein/min