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Table 3 Cytotoxicity (LC50 in µg/mL) of eight compounds isolated from Entada abyssinica and their selectivity index (SI) values against normal and cancer cell lines

From: Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)

Compounds Vero LC50 THP-1 RAW 264.7
LC50 SI LC50 SI
1 22.42 ± 2.48a 9.62 ± 0.59a 7.32 4.56 ± 0.020a 15.44
2 44.83 ± 2.83b nd 16.44 ± 0.20b 4.28
3 53.76 ± 2.05c nd 41.90 ± 0.43c 1.68
4 47.46 ± 0.63b,d 49.78 ± 3.03b 1.41 52.30 ± 1.30d 1.35
5 41.91 ± 1.85b,e 21.81 ± 1.11c 3.23 16.10 ± 1.00b 4.37
6 30.58 ± 3.09f 75.00 ± 1.68d 0.94 36.92 ± 1.27e 1.91
7 55.65 ± 0.30c 84.28 ± 3.30e 0.84 19.12 ± 0.25f 3.68
8 80.50 ± 4.83g 65.00 ± 6.88d,f 1.08 86.55 ± 4.61g 0.81
Doxorubicin 9.35 ± 0.66h nd 0.5 ± 0.00h nd
Puromycin 5.32 ± 0.90i 0.4 ± 0.02g 176.03 1.15 ± 0.17i 61.23
  1. Data represent the mean ± SD of three independent experiments; values with different letters are significantly different at p < 0.05
  2. nd not determined, 100 µg/mL