Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)

Table 3 Cytotoxicity (LC₅₀ in µg/mL) of eight compounds isolated from Entada abyssinica and their selectivity index (SI) values against normal and cancer cell lines

Compounds	Vero LC₅₀	THP-1		RAW 264.7
Compounds	Vero LC₅₀	LC₅₀	SI	LC₅₀	SI
1	22.42 ± 2.48^a	9.62 ± 0.59^a	7.32	4.56 ± 0.020^a	15.44
2	44.83 ± 2.83^b	–	nd	16.44 ± 0.20^b	4.28
3	53.76 ± 2.05^c	–	nd	41.90 ± 0.43^c	1.68
4	47.46 ± 0.63^b,d	49.78 ± 3.03^b	1.41	52.30 ± 1.30^d	1.35
5	41.91 ± 1.85^b,e	21.81 ± 1.11^c	3.23	16.10 ± 1.00^b	4.37
6	30.58 ± 3.09^f	75.00 ± 1.68^d	0.94	36.92 ± 1.27^e	1.91
7	55.65 ± 0.30^c	84.28 ± 3.30^e	0.84	19.12 ± 0.25^f	3.68
8	80.50 ± 4.83^g	65.00 ± 6.88^d,f	1.08	86.55 ± 4.61^g	0.81
Doxorubicin	9.35 ± 0.66^h	–	nd	0.5 ± 0.00^h	nd
Puromycin	5.32 ± 0.90ⁱ	0.4 ± 0.02^g	176.03	1.15 ± 0.17ⁱ	61.23

Data represent the mean ± SD of three independent experiments; values with different letters are significantly different at p < 0.05
nd not determined, – 100 µg/mL

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