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Table 2 Bioactivity of purified rhGM-CSF from P. pastoris and S. cerevisiae using IEC or HIC

From: Pichia pastoris versus Saccharomyces cerevisiae: a case study on the recombinant production of human granulocyte-macrophage colony-stimulating factor

 

ED50 (pg/mL)

LU (units/mg)

Response curve range (OD unit)

GM-CSF from P. pastoris (IEC)

84.5

11.8 × 106

0.26

GM-CSF from P. pastoris (HIC)

198.7

5.0 × 106

0.32

GM-CSF from P. pastoris (crude)

1876

0.53 × 106

0.06

GM-CSF from S. cerevisiae (IEC)

27,880

0.36 × 105

0.49

GM-CSF from S. cerevisiae (crude)

37,238

0.27 × 105

0.05