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Table 1 Case reports of early allograft dysfunction due to nephrocalcinosis

From: Successful treatment of early allograft dysfunction with cinacalcet in a patient with nephrocalcinosis caused by severe hyperparathyroidism: a case report

 

Iguchi et al.

Sewpaul et al.

Backman et al.

Wong et al.

Manfro et al.

Patient gender/age (year)

Female/56

Male/48

Male/36

Female/44

Male/36

Allograft type

Living-related

Living-related

Living

Cadaveric

Cadaveric

Biopsy time after transplant w/nephrocalcinosis

10 days

7 days

3 days

18 days (biopsy at 3 days showed acute cellular rejection w/o calcium crystals)

15 days

Other lesions

Borderline acute rejection

Acute tubular necrosis

None

Acute tubular necrosis

Acute tubular necrosis

Serum calcium

Slightly increased

Markedly increased

Normal

Normal

Normal

Serum phosphate

Slightly increased

Slightly increased

Normal

Markedly increased

Markedly increased

Follow-up

Graft function improved after supportive treatment

Parathyroidectomy improved hypercalcemia and graft function

Parathyroidectomy improved graft function. Decreased amount of calcium crystals in follow-up biopsy

Graft loss within 5 months. Serial biopsy showed gradual increase in calcium crystals and tubulointerstitial fibrosis

Repeat biopsy at day 85 showed no calcification. Stable graft function at 1 year