Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report

Table 1 Altered resting-state functional connectivity with DMN during spontaneous migraine attack compared to interictal phase

Conn	Brain regions	Side	Number of voxels	MNI coordinates			Conn	Brain regions	Side	Number of voxels	MNI coordinates
Conn	Brain regions	Side	Number of voxels	X	Y	Z	Conn	Brain regions	Side	Number of voxels	X	Y	Z
Increased	Lingual gyrus, cuneus	B	4691	26	−66	4	Decreased	ITG, Fusiform gyrus	L	2125	−56	−72	−14
	IOG	L	156	−36	−100	−8			R	1004	58	−30	−34
	IPG, PostCG, PreCG, Thal, Caud, hypothalamus	B	10,486	−46	−24	44		ITG	L	80	−68	−32	−20
	ITG	R	61	52	−18	−36		MidTG	R	516	58	2	−10
	STG	L	55	−30	10	−26		STG	L	384	−66	−24	8
		L	253	−60	10	−2			R	280	40	16	−38
	MidTG	R	423	46	−68	16		Fusiform gyrus	R	467	34	−32	−18
	*dMFC*, SFG	B	1449	10	56	24		Gyrus rectus, *vMFC*	L	668	−6	40	−24
	SFG	L	86	−20	56	14		MidFG	R	451	22	20	38
	*dMFC*	L	63	−4	28	58			L	129	−34	40	−2
	MidFG	R	289	38	62	−16			L	60	−24	−4	56
		R	87	42	36	40		SFG	L	573	−22	26	54
	SMA	B	68	−4	16	64			R	70	8	4	72
	PreCG, PostCG	R	1585	36	−10	50		IFG	R	278	34	34	−18
	PreCG	L	145	−10	−34	70		PreCG	R	79	16	−32	66
	Insula, claustrum, putamen, pallidum	R	327	36	−18	4		Angular gyrus	R	943	42	−66	36
	MCC	R	189	16	−2	40			L	1403	−38	−68	36
	PHC	R	52	28	−20	−26		PostCG	R	84	46	−24	64
	Pons	L	52	−4	−22	−26		*PCC, precuneus*	R	438	6	−52	16
	Putamen	L	325	−26	16	0			R	101	2	−38	8
	Cerebellum	R	613	28	−56	−60		MCC	R	133	14	−34	24
		L	336	−28	−54	−52			B	127	4	−34	36
		R	177	4	−70	−40		Hippocampus	R	288	22	−16	−6
		L	610	−30	−86	−28		Cerebellum	R	65	10	−54	−52
		L	172	−24	−46	−28			B	182	2	−44	−12
		R	133	36	−72	−24

Italic part of DMN; bold part of pain matrix
Conn connectivity, R right, L left, B bilateral, dMFC dorsal medial frontal cortex, IFG inferior frontal gyrus, IOG inferior occipital gyrus, IPG inferior parietal gyrus, ITG inferior temporal gyrus, MCC middle cingulate gyrus, MidFG middle frontal gyrus, MidTG middle temporal gyrus, PCC posterior cingulate cortex, PHC parahippocampal gyrus, PostCG postcentral gyrus, PreCG precentral gyrus, SFG superior frontal gyrus, SMA supplementary motor area, STG superior temporal gyrus, Thal thalamus, Caud caudate, vMFC ventral medial frontal cortex (p < 0.05, FDR corrected; cluster size limit = 50 voxel)

ISSN: 1756-0500