Fig. 4
From: A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy
The co-expression of Pdxk-RNAi with Buffy suppresses the Pdxk-induced phenotypes. a The co-expression of Buffy with Pdxk-RNAi result in the suppression of the observed phenotype of decreased survival. Genotypes are Ddc-Gal4 UAS-Buffy/UAS-lacZ and Ddc-Gal4 UAS-Buffy/Pdxk-RNAi. Longevity is shown as percent survival [P < 0.05, determined by log-rank (Mantel–Cox) test with n ≤ 200]. b The co-expression of Pdxk-RNAi with Buffy in the Ddc-Gal4-expressing neurons results in the suppression of the age-dependent loss in climbing ability. The genotypes are Ddc-Gal4 UAS-Buffy/UAS-lacZ and Ddc-Gal4 UAS-Buffy/Pdxk-RNAi. Analysis was done by nonlinear fitting of the climbing curves and significance was determined by comparing the 95% confidence interval. Error bars indicate SEM and n = 50