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Table 4 Post-hoc comparison of abstracts that were subsequently published in lower versus higher impact journals

From: Publication bias in animal research presented at the 2008 Society of Critical Care Medicine Conference

Potential predictor variable

Published in lower impact (n = 32)

Published in higher impact (n = 30)

p valuea

Type of presentation

 Oral (vs. poster) presentation

7 (22%)

7 (23%)

0.99

 Research location in North America

17 (53%)

23 (77%)

0.07

Methodological quality variables

 Randomized

7 (22%)

10 (33%)

0.40

 Blinded

0 (0%)

0 (0%)

–

 Primary outcome given

6 (19%)

7 (23%)

0.76

 Numbers with denominators

1 (3%)

3 (10%)

0.35

 Number of animals stated

14 (44%)

16 (53%)

0.61

 Sample size calculation

0 (0%)

0 (0%)

–

Ethical quality variables

 Highest species rodent

20 (63%)

15 (50%)

0.32

 >19 animals used

6 (19%)

9 (30%)

0.30

Outcome variables

 Main outcomes positive

28 (88%)

29 (97%)

0.36

 Statistically significant result

17 (53%)

18 (60%)

0.59

Type of animal model

 Sepsis

9 (28%)

18 (60%)

0.02

 Drug used

14 (44%)

10 (33%)

0.44

 Surgery performed

12 (38%)

13 (43%)

0.80

 Animals stated to be killed

19 (59%)

15 (50%)

0.61

  1. aComparisons made using Fisher’s Exact or Chi square test. For published articles, the journal impact factors were: mean 5.2 (SD 4.9), median 4.5 [IQR 2.4, 7.4], range 0.02–30.36; 5 articles were published in journals with impact factor >10